Molecular Imaging in the Treatment of Kaposi's Sarcoma

分子影像治疗卡波西肉瘤

• 批准号: 8566681
• 负责人: RICHARD Frederick AMBINDER
• 金额: $ 17.79万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8566681
• 关键词: Biometry; Bortezomib; Clinical; Collection; Development; Ensure; Environment; Enzymes; Equipment; Extracellular Matrix; Five-Year Plans; Funding; Future; Goals; Image; Imaging technology; Kaposi Sarcoma; Lung; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of pancreas; Mediating; Metastatic Neoplasm to the Bone; Metastatic Prostate Cancer; Modality; Molecular; Neoplasm Metastasis; Oncologist; Pathologist; Pathway interactions; Patients; Positron-Emission Tomography; Radiation; Renal carcinoma; Research; Research Infrastructure; Research Personnel; Resources; Scientist; Structure; Surgeon; Translating; Translations; Treatment Efficacy; Treatment outcome; base; bench to bedside; career development; effective therapy; epithelial to mesenchymal transition; hypoxia inducible factor 1; imaging modality; imaging probe; improved; in vivo Cellular and Molecular Imaging Centers; melanoma; molecular imaging; molecular oncology; oncology; optical imaging; programs; radiologist; single photon emission computed tomography; theranostics; tumor progression

For our next five-year plan we have aligned ourselves to the goals of discovering, developing, and translating molecular imaging technologies to understand, detect, and treat cancer. Our efforts and expertise will be applied collectively and synergistically for this purpose. By engaging and integrating clinical oncologists, radiologists, pathologists, and surgeons within every aspect of the program, we have ensured the translation of our most exciting discoveries to improve treatment outcome in patients. This unique collection of highly interactive research-scientists and clinician-scientists within an environment rich in multi-modality imaging expertise and equipment is necessary to make the catapulting advances and discoveries that are essential to find effective treatments for cancer. The JHU ICMIC Program consists of four research components, four developmental projects, four resources, and a career development component. The four research components have a major emphasis on clinical translation and cover different aspects of understanding, detecting, and treating cancer. These are (i) theranostic imaging of metastatic prostate cancer, (ii) BETR (bortezomib-induced enzyme targeted radiation) theranostics for Kaposi's sarcoma (KS), (iii) exchange transfer-based molecular MRI in oncology and (iv) molecular imaging of the extracellular matrix (ECM) and its avenues for metastasis. Similarly, the four developmental projects cover a range of topics, such as (i) force propagation in melanoma cancer progression, (ii) imaging peri-tumoral stromal depletion as a surrogate for treatment efficacy in pancreatic cancer, (iii) lung-specific Twist mediated epithelial to mesenchymal transition (EMT) in lung premetastatic niche, and (iv) blockade of the hypoxia inducible factor (HIF)-1 pathway in bone metastasis from renal cancer. We have structured four specialized resources (the Administrative Resource, the Molecular Oncology Resource, the Imaging and Probes Resource, and the Biostatistics Resource) to provide the infrastructure to support the current and future projects of the JHU ICMIC. The Career Development Component is structured with the purpose of creating independently funded investigators who will, in the future, become leaders in the field.

对于下一个五年计划，我们与发现，发展和 翻译分子成像技术以理解，检测和治疗癌症。我们的努力和 专业知识将集体和协同应用于此目的。通过参与和整合 临床肿瘤学家，放射科医生，病理学家和外科医生在该计划的各个方面，我们都有 确保我们最令人兴奋的发现的翻译以改善患者的治疗结果。这 高度互动研究科学家和临床医生在富人环境中的独特集合 在多模式成像中的专业知识和设备对于弹射的进步是必要的 发现有效治疗癌症至关重要的发现。 JHU ICMIC计划包括 四个研究组件，四个发展项目，四个资源和一个职业发展 成分。这四个研究组件主要重点是临床翻译和覆盖 理解，检测和治疗癌症的不同方面。这些是（i）theranotic成像的 转移性前列腺癌，（ii）betr（硼替佐米诱导的酶靶向辐射）疗法用于 Kaposi的肉瘤（KS），（III）基于肿瘤学和（IV）分子的基于交换转移的分子MRI 细胞外基质（ECM）及其转移的途径的成像。同样，这四个发展 项目涵盖了一系列主题，例如（i）黑色素瘤癌症进展中的力传播，（ii）成像 肿瘤周日基质消耗是胰腺癌治疗疗效的替代物，（iii）肺特异性 在肺前转移壁裂中的间质转变（EMT）的上皮上皮的扭曲，（iv）阻断 肾癌骨转移中的缺氧诱导因子（HIF）-1途径。我们已经结构了 四个专业资源（行政资源，分子肿瘤资源，成像 并探索资源以及生物统计学资源）提供基础架构以支持当前 以及JHU ICMIC的未来项目。职业发展组成部分是有目的的 建立独立资助的调查人员将来会成为该领域的领导者。