Virology

病毒学

基本信息

批准号：
7685030
负责人：
JOHN Christopher KAPPES
金额：
$ 18.6万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-06-15 至 2014-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7685030
关键词：
AIDS/HIV problem Acquired Immunodeficiency Syndrome Address Arts Biological Assay Cell Line Clinical Consultations Containment Development Engineering Ensure Environment Equipment Faculty Fee-for-Service Plans Fostering Goals Grant HIV Human Resources Immunologics Immunology Knowledge Laboratories Life Methods Mission Molecular Molecular Biology Nature Operative Surgical Procedures Pathogenesis Phase Plasmids Policies Proteins Quality Control Reagent Recombinant Proteins Recombinants Research Research Personnel Resources Safety Services Site Strategic Planning Structure Supervision Techniques Technology Transfer Training Training and Education Vaccine Research Viral Viral Vector Work base cost experience gene cloning genetically modified cells laboratory facility multidisciplinary programs protein expression safety practice success tool virology virus culture

项目摘要

The goals of the VC are to enable, broaden and enhance HIV/AIDS research by providing state-of-the-art BSL-2-3 laboratory facilities and equipment, experienced and dedicated professional staff, education, training, virology-specific research materials and assays and protein expression capabilities, all to support multidisciplinary, investigator-initiated basic and clinical HIV/AIDS research. Each of our specific aims represent significant value-added to HIV/AIDS research and the overall CFAR mission as they (i) enable live HIV research among all UAB investigators, (ii) foster the development of HIV/AIDS research by new investigators, (iii) broaden the research capabilities among CFAR faculty, and (iv) encourage research that is translational and multidisciplinary in nature. The services of VC are integral to the AIDS Center as they provide critical support to numerous multidisciplinary basic and clinical HIV/AIDS research programs. The specific aims for the VC are as follows: 1. To provide and maintain state-of-the-art BSL 2-3 laboratory facilities that are necessary to conduct "live" HIV research. 2. To provide safety education and training, and ongoing supervision for all faculty and staff that work in the BSL 2-3 Laboratory. 3. To augment AIDS research capabilities through consultation, assay-specific training, and provision of standardized assays and defined molecular and virologic reagents. 4. To develop specialized genetically engineered tools and assays, including cell lines and viral vectors, to help address new and important investigative challenges in HIV/AIDS research. 5. To continue to offer CFAR investigators the molecular biology services, reagents, and training, that allow a rapid progression from cloning of genes to structure and/or function studies of the gene product. This renewal application reflects important changes that have occurred in the academic HIV/AIDS environment nationally and at UAB since this grant was last competitively renewed. The critical services of two cores that were previously operated independently, the Central Virus Culture Core and the Molecular Biology Core, have been combined into a single core that is now referred to as the Virology Core (VC). This strategy is based on similarities in the nature of virology services offered by the two previous cores and is meant to ensure that we are able to retain and continue to provide critical value-added services, while maximizing proficient utilization of precious CFAR resources.

VC 的目标是通过提供最先进的 BSL-2-3 来实现、扩大和加强 HIV/AIDS 研究实验室设施和设备、经验丰富且敬业的专业人员、教育、培训、病毒学专业研究材料和分析以及蛋白质表达能力，所有这些都是为了支持多学科、研究者发起的艾滋病毒/艾滋病的基础和临床研究。我们的每一个具体目标都为艾滋病毒/艾滋病带来了巨大的附加值研究和总体 CFAR 使命，因为它们 (i) 使所有 UAB 研究人员能够进行实时艾滋病毒研究，(ii) 促进新研究者推动艾滋病毒/艾滋病研究的发展，(iii) 扩大 CFAR 教师的研究能力， (iv) 鼓励转化性和多学科性质的研究。 VC 的服务是不可或缺的艾滋病中心为众多多学科基础和临床艾滋病毒/艾滋病研究提供重要支持程序。 VC的具体目标如下： 1. 提供并维护进行必要的最先进的 BSL 2-3 实验室设施 “现场”艾滋病毒研究。 2、对所有在校工作的教职员工进行安全教育和培训，并进行持续的监督。 BSL 2-3 实验室。 3. 通过咨询、特定检测培训和提供标准化测定和明确的分子和病毒学试剂。 4. 开发专门的基因工程工具和检测方法，包括细胞系和病毒载体，帮助应对艾滋病毒/艾滋病研究中新的重要调查挑战。 5. 继续为 CFAR 研究人员提供分子生物学服务、试剂和培训，允许从基因克隆到基因结构和/或功能研究的快速进展产品。此更新申请反映了艾滋病毒/艾滋病学术环境中发生的重要变化自从该补助金上次竞争性更新以来，在全国范围内和在 UAB 都得到了支持。两个核心的关键服务分别是之前独立运作的中央病毒培养核心和分子生物学核心，已被组合成一个核心，现在称为病毒学核心（VC）。该策略基于以下方面的相似之处：前两个核心提供的病毒学服务的性质，旨在确保我们能够保留和继续提供关键的增值服务，同时最大限度地熟练利用宝贵的CFAR资源。