Biostatistics Core

生物统计学核心

• 批准号: 8379848
• 负责人: SARAH E HOLTE
• 金额: $ 6.63万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8379848
• 关键词: Address; Area; Autologous; Binomial Distribution; Biological Assay; Biometry; Biostatistics Core; Characteristics; Clinical; Clinical Data; Collaborations; Complex; Computer Simulation; Computer software; Data; Data Analyses; Data Collection; Data Quality; Data Reporting; Data Set; Databases; Development; Doctor of Philosophy; Event; Evolution; Generations; Genital system; Genomics; HIV; HIV Infections; HIV-1; Immune response; In Vitro; Individual; Infection; Inflammation; Laboratories; Laboratory Procedures; Linear Regressions; Logistic Regressions; Measurement; Measures; Medical Research; Methods; Modeling; Mutation; Normal Statistical Distribution; Outcome; Population; Process; Programming Languages; Proteome; Quality Control; Regression Analysis; Relative (related person); Research; Research Design; Research Infrastructure; Research Personnel; Resources; Role; Statistical Data Interpretation; Statistical Methods; Statistical Models; Testing; Time; Variant; Vertebral column; Viral; Viral Genes; Viral Proteins; Virus; Work; cost; data management; design; experience; fitness; in vivo; insight; instrument; interest; mathematical model; mutant; novel; programs; quality assurance; research study; theories; tool; transmission process; virology

Statistical and database support for the Seattle Primary Infection Program The need for biostatistics and other quantitative support is part of most medical research and as such, the SeaPIP Projects will utilize the resources of the Biostatistics Core on some level in nearly every type of research conducted. Recent advances in data collection and measurement instruments result in more and more complex data types, such as viral and cellular genomics, viral dynamics, and sophisticated measures of immune responses: all areas that would benefit from input and collaboration with statisticians. By including MSlevel biostatisticians for routine analyses and PhD-level biostatisticians for collaboration on more advanced analyses, the SeaPIP Biostatistics Core is well equipped to handle these complex new problems, in addition to providing standard and necessary classical biostatistics support. In addition, given the diversity of projects requiring Biostatistical support, the Core can provide the infrastructure needed to integrate the disparate statistical and scientific activities of the Program Project as a whole, and identify opportunities for inter-project hypothesis generation and exploratory analyses. The Biostatistics Core will use MS-level SAS programmers and statisticians across all three projects which will provide efficiency and breadth of experience to the Program overall. Furthermore, Drs. Holte and Hughes will have regular interactions to discuss Program statistical activities so that each Project can benefit from statistical scientific insights gained in the analysis from all three Projects in the Program. Finally, the most successful collaborations between statisticians and clinical and laboratory researchers is achieved when the same researchers work together over long periods of time. Dr. Holte has many years of experience in collaborating with the SeaPIP investigators, so that she is well equipped to continue to support the quantitative needs of this scientific program.

西雅图主要感染计划的统计和数据库支持 对生物统计学和其他定量支持的需求是大多数医学研究的一部分，因此， Seapip项目将在某种程度上利用生物统计学核心的资源，几乎每种类型 研究进行了。数据收集和测量工具的最新进展导致更多和 更复杂的数据类型，例如病毒和细胞基因组学，病毒动力学以及精致的测量 免疫反应：所有与统计学家的投入和合作中受益的领域。通过包括MSLevel生物统计学家进行常规分析和博士学位生物统计学家进行更高级分析的合作，Seapip Biostatistics Core具有很好的能力来解决这些复杂的新问题，此外还提供了标准和必要的经典生物统计学支持。 此外，鉴于需要生物统计支持的项目多样性，核心可以提供 基础架构将整个计划项目的不同统计和科学活动整合在一起，并确定项目间假设产生和探索性分析的机会。生物统计学核心将在所有三个项目中使用MS级SAS程序员和统计学家，这将为该计划提供效率和广度。此外，博士。 Holte和Hughes将定期进行讨论计划统计活动，以便每个项目都可以从该计划中所有三个项目的分析中获得的统计科学见解受益。 最后，当统计学家与临床和实验室研究人员之间最成功的合作是在长期长时间共同努力时实现的。 Holte博士在与Seapip调查人员合作方面拥有多年的经验，因此她有能力继续支持该科学计划的定量需求。