Clinical

临床

• 批准号: 7685009
• 负责人: RAJESH T GANDHI
• 金额: $ 66.11万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-11 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7685009
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Acute; Address; Basic Science; Caring; Chronic; Clinical; Databases; Development; Disease; Funding; Goals; HIV; HIV Infections; Hepatitis C; Immune response; International; Life; Mission; Opportunistic Infections; Patient Care; Patients; Population; Recording of previous events; Research; Research Infrastructure; Research Personnel; Sampling; Seminal; Site; Specimen; Translational Research; Tuberculosis; Universities; Virus; antiretroviral therapy; bench to bedside; clinical infrastructure; design; improved; insight; member; outreach program; repository; stem; success; treatment trial

HU CFAR investigators have a long history of high impact contributions stemming from bench-to-bedside research. The CFAR Clinical Core activities have been absolutely essential to the success of these HIV/AIDS research efforts at Harvard by providing the clinical infrastructure, clinical samples and clinical information critical to these studies; these components of translational research are either not funded or are only inadequately funded by other support mechanisms. With the expansion to a Harvard-wide CFAR, the Clinical Core continues to set new goals and modify its mission to be maximally responsive to its members, in particular now with an expanding international focus to this Core. To address ongoing needs of HU CFAR investigators, we now propose to accomplish the following specific aims: ¿ To provide infrastructure support for HU CFAR investigators conducting clinical and basic science research related to HIV/AIDS and its associated opportunistic infections, domestically and internationally. ¿ To develop and provide access to databases and clinical specimen repositories from wellcharacterized HIV-infected populations domestically and internationally. ¿ To support educational and outreach programs designed to facilitate clinical and translational research at HU and at international sites associated with HU CFAR investigators.

HU CFAR 研究人员有着从实验室到临床的高影响力贡献的悠久历史 CFAR 临床核心活动对于这些研究的成功至关重要。 哈佛大学的艾滋病毒/艾滋病研究工作通过提供临床基础设施、临床样本和临床 对这些研究至关重要的信息；转化研究的这些组成部分要么没有得到资助，要么得到了资助 随着CFAR扩展到哈佛范围内，其他支持机制的资金不足。 Clinical Core 继续设定新目标并修改其使命，以最大程度地响应其成员， 特别是现在国际社会对这一核心的关注不断扩大，以满足 HU CFAR 的持续需求。 调查人员，我们现在建议实现以下具体目标： ¿为 HU CFAR 研究人员进行临床和基础科学研究提供基础设施支持 国内外有关艾滋病毒/艾滋病及其相关机会性感染的研究 国际上。 ¿开发并提供对经过充分表征的数据库和临床标本存储库的访问 国内外艾滋病毒感染者。 ¿支持旨在促进临床和转化的教育和外展计划 HU 以及与 HU CFAR 研究人员相关的国际站点的研究。