PERLECAN AND HEPARANASE IN CARTILAGE GROWTH AND HEALING

PERLECAN 和乙酰肝素酶在软骨生长和愈合中的作用

• 批准号: 7959490
• 负责人: MARY C FARACH-CARSON
• 金额: $ 31.59万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959490
• 关键词: Address; Adult; Age; Biology; Cartilage; Centers of Research Excellence; Chondrogenesis; Complex; Computer Retrieval of Information on Scientific Projects Database; Degenerative polyarthritis; Embryonic Development; Engineering; Enzymes; Funding; Grant; Growth; Healed; Heparan Sulfate Proteoglycan; Heparitin Sulfate; In Vitro; Injury; Institution; Maintenance; Mentors; Mutation; Organism; Play; Process; Research; Research Personnel; Resources; Role; Science; Source; Structure; United States National Institutes of Health; Woman; healing; heparanase; mouse model; perlecan; professor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In the first project, Dr. Farach-Carson proposes to define precisely the structural and functional roles that perlecan (Pln) and its associated heparan sulfate (HS) proteoglycan chains play in cartilage biology. HS proteoglycans have recently emerged as key regulators of cartilage biology and play critical roles during embryonic development, in maintenance of cartilage structures in the adult organism, and in regrowth of damaged cartilage resulting from age, osteoarthritis or injury. Using a combination of in vitro chondrogenesis models and mice harboring mutations in Pln or HS biosynthetic enzymes, Dr. Farach-Carson et al. will address the hypothesis that Pln and heparanase I are essential players in normal chondrogenesis and cartilage healing, and that their complex roles in these processes are associated with specialized functions encrypted within the various domains and require the presence and turnover of HS. Dr. Farach-Carson is a full professor and will not have a mentor.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 在第一个项目中，Farach-Carson 博士建议精确定义基底膜聚糖 (Pln) 及其相关的硫酸乙酰肝素 (HS) 蛋白聚糖链在软骨生物学中发挥的结构和功能作用。 HS 蛋白多糖最近已成为软骨生物学的关键调节因子，在胚胎发育、成人机体软骨结构的维持以及因年龄、骨关节炎或损伤引起的受损软骨的再生过程中发挥着关键作用。 Farach-Carson 博士等人结合使用体外软骨形成模型和携带 Pln 或 HS 生物合成酶突变的小鼠。将提出这样一个假设：Pln 和乙酰肝素酶 I 在正常软骨形成和软骨愈合中是重要的参与者，并且它们在这些过程中的复杂作用与各个域内加密的特殊功能相关，并且需要 HS 的存在和更新。法拉赫-卡森博士是一名正教授，不会有导师。