P 3: PSYCHOACTIVITY OF CANNABINOIDS & INTERACTIO W/ DELTA-9-TETRAHYDROCANNABINOL

P 3：大麻素的心理活性

• 批准号: 7959629
• 负责人: SAMIR A ROSS
• 金额: $ 19.09万
• 依托单位: UNIVERSITY OF MISSISSIPPI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959629
• 关键词: Biological; Biological Factors; Cannabinoids; Cannabis; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Individual; Institution; Research; Research Personnel; Resources; Source; Tetrahydrocannabinol; United States National Institutes of Health; endogenous cannabinoid system

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aims of this project are as follows: 1. Isolate and structurally analyze different cannabinoids, especially from the polyhydroxylated cannabitriol group and non-cannabinoid phenolic compounds from cannabis extract, whose biological activity is unknown. 2. Confirm that the mechanism of action of the isolated compounds involves an interaction with the endogenous cannabinoid system. 3. Study the psychoactivity of the isolated compounds and compare it with that of delta-9-THC. 4. Study the interaction of delta-9-THC with the individual isolated compounds and determine their contribution to the overall biological activities of cannabis.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目的具体目标如下： 1. 分离和结构分析不同的大麻素，特别是来自大麻提取物的多羟基化大麻三醇基团和非大麻素酚类化合物，其生物活性未知。 2. 确认分离化合物的作用机制涉及与内源性大麻素系统的相互作用。 3. 研究分离化合物的精神活性，并与 delta-9-THC 进行比较。 4. 研究 delta-9-THC 与单个分离化合物的相互作用，并确定它们对大麻整体生物活性的贡献。