PROTEOMICS REVEALS RAPIDLY EVOLVING POLLEN TUBE PROTEINS

蛋白质组学揭示快速进化的花粉管蛋白质

• 批准号: 8365839
• 负责人: WILLIE J SWANSON
• 金额: $ 0.65万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365839
• 关键词: Biology; Candidate Disease Gene; Diatoms; Drosophila genus; Evolution; Fertility; Funding; Fungal Genome; Genes; Goals; Grant; Human; Mammals; National Center for Research Resources; Organism; Pollen Tube; Principal Investigator; Proteins; Proteomics; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; Work; abalone; cost; egg; reproductive; sperm cell

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. A recurring observation in the study of reproductive proteins is their rapid, adaptive evolution. This phenomenon occurs in organisms as diverse as diatoms and humans. The long-term goal of our research is to understand the diversity of reproductive proteins and the functional consequences of their divergence, which could involve problems in fertility and speciation due to a mismatch of sperm-egg recognition molecules. We work with a variety of organisms, including Drosophila, abalone (Haliotis), and mammals. A common theme throughout our research is identifying genes subjected to positive selection (adaptive evolution), indicating potentially functionally important candidate genes.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 生殖蛋白研究中的反复观察是它们的快速，适应性进化。这种现象发生在像硅藻和人类一样多样化的生物中。我们研究的长期目标是了解生殖蛋白的多样性及其差异的功能后果，这可能涉及由于精子 - 卵子识别分子不匹配而导致的生育和物种形成问题。 我们与包括果蝇，鲍鱼（Haliotis）和哺乳动物在内的各种生物合作。整个研究中的一个共同主题是识别受到阳性选择（自适应进化）的基因，表明潜在的功能重要的候选基因。