CRYSTAL STRUCTURE OF DCR3-TL1A COMPLEX

DCR3-TL1A复合物的晶体结构

• 批准号: 7955210
• 负责人: STEVEN G ALMO
• 金额: $ 0.53万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955210
• 关键词: Complex; Computer Retrieval of Information on Scientific Projects Database; Destinations; Disease; Dissection; Funding; Grant; Immune response; Immunosuppressive Agents; Institution; Ligand Binding; Ligands; Proteins; Research; Research Personnel; Resources; Rheumatoid Arthritis; Source; Structure; Therapeutic; Tumor Necrosis Factor Receptor; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; United States National Institutes of Health; decoy receptor 3; human disease; receptor; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Decoy Receptor 3 (DcR3) is a secreted immunosuppressive protein that belongs to the Tumor Necrosis Factor (TNF) receptor superfamily. The dissection of DcR3's functional mechanism is complicated by its capacity to neutralize three different TNF ligands: FasL, LIGHT, and TL1A. Each of these ligands binds distinct functional receptors and subsequently directs immune responses to different destinations. The understanding of the interactions between DcR3 and its ligands may provide therapeutic opportunities to a variety of human diseases, including Chron's disease and rheumatoid arthritis.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 诱饵受体 3 (DcR3) 是一种分泌型免疫抑制蛋白，属于肿瘤坏死因子 (TNF) 受体超家族。 DcR3 的功能机制的剖析因其中和三种不同 TNF 配体（FasL、LIGHT 和 TL1A）的能力而变得复杂。这些配体中的每一个都结合不同的功能受体，随后将免疫反应引导至不同的目的地。对DcR3及其配体之间相互作用的了解可能为多种人类疾病提供治疗机会，包括慢性病和类风湿性关节炎。