STRUCTURAL AND MECHANISTIC STUDIES OF THE PANTOCIN A BIOSYNTHESIS

全解菌素A生物合成的结构和机理研究

• 批准号: 7955137
• 负责人: Jon Clardy
• 金额: $ 2.14万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955137
• 关键词: Affect; Anabolism; Antibiotics; Apple; Biochemistry; Computer Retrieval of Information on Scientific Projects Database; Disease; Erwinia amylovora; Fire - disasters; Funding; Gram-Negative Bacteria; Grant; Growth; Institution; Pantoea agglomerans; Pear; Peptides; Plant Diseases; Plants; Research; Research Personnel; Resources; Source; Trees; United States National Institutes of Health; base; novel; pantocin A; structural biology; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Fire blight is a devastating plant disease that is caused by Erwinia amylovora, a Gram-negative bacterium. The disease affects more than a hundred rosaceous plant species, including the commercially important apple and pear trees. Pantocin A is a novel peptide-based antibiotic produced by Pantoea agglomerans, another Gram-negative bacterium, to inhibit the growth of E. amylovora. This project attempts to utilize both structural biology and biochemistry tools to elucidate the biosynthesis of pantocin A.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 火疫病是一种毁灭性的植物病害，由梨火疫病菌（一种革兰氏阴性细菌）引起。这种疾病影响一百多种蔷薇科植物，包括商业上重要的苹果树和梨树。 Pantocin A 是一种新型肽类抗生素，由另一种革兰氏阴性细菌成团泛菌 (Pantoea agglomerans) 产生，可抑制梨火疫病菌 (E. amylovora) 的生长。该项目试图利用结构生物学和生物化学工具来阐明 pantocin A 的生物合成。