TOWARDS THE COMPLETE CHARACTERIZATION OF NEUREXIN TRANS-SYNAPTIC LIGANDS

神经毒素跨突触配体的完整表征

• 批准号: 8365894
• 负责人: ANIRVAN GHOSH
• 金额: $ 0.74万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365894
• 关键词: Adhesions; Alternative Splicing; Behavior; Biology; Brain; Code; Funding; Fungal Genome; Genes; Grant; Ligands; National Center for Research Resources; Neurons; Organism; Principal Investigator; Protein Isoforms; Proteins; Proteome; Research; Research Infrastructure; Resources; Source; Synapses; United States National Institutes of Health; cost; neural circuit; presynaptic; promoter; protein expression

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The identification and characterization of the trans-synaptic adhesion proteome may prove sufficient to break the synapse code. Determination of the trans-synaptic adhesion proteome may prove central to our eventual understanding of neuronal synaptic circuitry and brain wiring and in turn organism behavior. Historically, Neurexins (NRXNs) have been considered the most-likely presynaptic protein responsible for post-synaptic differentiation. NRXN protein expression is highly regulated (3 genes, alternative promoters, and massive alternative splicing) and it has been proposed that NRXNs may be present in thousands of isoforms within the mammalian brain.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 反式突触粘附蛋白组的识别和表征可能足以打破突触代码。跨突触粘附蛋白组的确定可能是我们最终对神经元突触电路和脑接线以及又有生物体行为的理解至关重要的。从历史上看，神经毒素（NRXN）被认为是导致突触后分化的最明显的突触前蛋白。 NRXN蛋白表达受到高度调节（3个基因，替代启动子和大量的替代剪接），并且已经提出，NRXN可能存在于哺乳动物大脑内的数千种同工型中。