Molecular and Cellular Mechanisms underlying function and dysfunction of Neural C

神经 C 功能和功能障碍的分子和细胞机制

• 批准号: 7859550
• 负责人: ANIRVAN GHOSH
• 金额: $ 71.41万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7859550
• 关键词: Molecular; Cellular; Mechanisms; underlying; function

DESCRIPTION (provided by applicant): This application targets the recruitment of new investigators o an interdisciplinary program whose focus is the structure and function of neural circuits in health and disease. The Program in Neural Circuits and Behavior (PNCB) will: 1) explore intensively on the biology of neural circuits and the behaviors they produce; and 2) tackle the most important questions in this field using a highly interdisciplinary approach. The PNCB builds on an extraordinarily rich neurosciences community of more than 120 members located at UCSD as well as at the Salk Institute, Scripps Research Institute, and the Burnham Institute. The PNCB is a recent joint creation of the School of Medicine, through the Department of Neurosciences, and the Division of Biological Sciences, through the Section on Neurobiology. The Chairs of the Section (Anirvan Ghosh) and the Department (William Mobley) have committed energy and resources to what they view as the most important next step for the neurosciences -" to decipher the structure and function neural circuits in the normal brain and in brains affected by neurological disorders". PNCB existing members are Robert Malinow, Jeffrey Isaacson and Massimo Scanziani. All occupy space in the CMG building; the new recruits would also be located there to enhance all aspects of career development. One of the new recruits would develop and use new optogenetic tools for imaging function. The other would examine circuit function in mouse models, including models of disease. Thus, they would bring new technologies and concepts to UCSD while benefitting immensely from a nurturing neuroscience community. The PNCB will also include about 20 additional members of the greater community whose work is in neural circuits at levels of analysis ranging from genes to higher order behaviors. By establishing close links between PNCB members and clinicians and scientists in the greater UCSD campus (e.g. Chemistry, Pharmaceutical Chemistry, Physics, and Psychology), this new program will undoubtedly foster many new insights into the biology of neural circuits. Indeed, it is our expectation that our recruits and their colleagues will transform our understanding of the organization and function of neural circuits. PUBLIC HEALTH RELEVANCE: All brain functions are carried out through the activation of specific neural circuits. Conversely, all disorders of brain function are due to disruption of specific circuits. Because we know little about the structure and function of neural circuits, we do not understand how circuits fail in brain disorders. Herein we propose to recruit key members of a multidisciplinary team to explore the function of circuits in health and disease.

描述（由申请人提供）：本申请的目标是招募新的研究人员o跨学科计划，其重点是神经回路在健康和疾病中的结构和功能。神经回路和行为的程序（PNCB）将：1）深入探讨神经回路的生物学及其产生的行为； 2）使用高度跨学科的方法解决该领域中最重要的问题。 PNCB建立在一个非常丰富的神经科学社区的基础上，该社区位于UCSD以及Salk Institute，Scripps Research Institute和Burnham Institute的120多个成员。 PNCB是最近通过神经科学系和生物科学系通过神经生物学的部分联合创建的。本节（Anirvan Ghosh）和部门（William Mobley）的椅子将能量和资源投入到他们认为是神经科学的最重要的下一步 - “破译正常大脑中的结构和功能神经回路，以及受神经系统疾病影响的大脑中的结构和功能神经回路”。 PNCB现有成员是Robert Malinow，Jeffrey Isaacson和Massimo Scanziani。所有占用CMG大楼的空间；新的新兵也将位于那里，以增强职业发展的各个方面。新的新兵之一将开发和使用新的光遗传学工具来进行成像功能。另一个将检查小鼠模型中的电路功能，包括疾病模型。因此，他们将把新技术和概念带到UCSD，同时从神经科学社区受益匪浅。 PNCB还将包括大约20个更大社区的成员，他们的工作是在神经回路中的分析水平，从基因到高阶行为。通过建立大型UCSD校园中PNCB成员与临床医生和科学家之间的密切联系（例如化学，药物化学，物理和心理学），该新计划无疑将促进许多对神经循环生物学的新见解。确实，我们期望我们的新兵及其同事将改变我们对神经回路组织和功能的理解。 公共卫生相关性：所有大脑功能都是通过激活特定神经回路来执行的。相反，所有大脑功能的疾病都是由于特定电路的破坏。因为我们对神经回路的结构和功能知之甚少，所以我们不了解电路如何在脑部疾病中失败。本文中，我们建议招募一个多学科团队的主要成员，以探索电路在健康和疾病中的功能。