BRAIN STRUCTURE WITH 7 TESLA MRI IN EPILEPSY

癫痫患者的脑结构与 7 特斯拉 MRI

• 批准号: 7955018
• 负责人: Thomas Reid Henry
• 金额: $ 1.28万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955018
• 关键词: Adult; Brain; Cerebrum; Clinical; Computer Retrieval of Information on Scientific Projects Database; Data; Detection; Diagnosis; Epilepsy; Fiber; Funding; Goals; Grant; Image; Imaging Techniques; Institution; Ipsilateral; Lesion; Limbic System; Magnetic Resonance Imaging; Noise; Patients; Protocols documentation; Research; Research Personnel; Resolution; Resources; Sensitivity and Specificity; Signal Transduction; Source; Spectrum Analysis; Structure; Testing; Tissues; United States National Institutes of Health; gray matter; healthy volunteer; improved; interest; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this project is to examine brain gray matter and white matter structure in adults with epilepsy, using 7 Tesla MRI, in order to test the hypothesis that the detection of relevant lesions will improve at 7T. Background. Current clinical imaging techniques have not detected and non-invasively diagnosed all relevant cerebral lesions. Many patients with epilepsy have normal brain MRI with current imaging protocols. The significant increase in signal to noise ratio at 7 Tesla provides improved spatial resolution and improved tissue contrast which may support increased sensitivity and specificity of lesion detection and characterization in epilepsy. Main Hypotheses 1) In an epilepsy sub-group with normal cerebral 3 T MRI, cerebral structural abnormalities can be detected with 7 T MRI. 2) In a sub-group with cerebral lesions on 3 T MRI, additional structural information concerning the lesions will be provided at 7 T. 3) In both sub-groups, fiber tracts of the limbic system ipsilateral to the ictal onset zone will be reduced in volume compared with those of the healthy adult subjects. The primary objectives of this study include the acquisition of very high spatial resolution T1w, T2w and SWI images in 10 control healthy volunteers and 20 fully diagnosed adult epileptic patients (10 with normal 3T MRI, 10 with cerebral lesions on 3T MRI). DTI data will be collected and fiber tract analysis will be performed in the selected regions of interest. These data will be analyzed qualitatively and volumetrically in order to test our hypotheses.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 该项目的总体目标是使用 7 特斯拉 MRI 检查成人癫痫患者的大脑灰质和白质结构，以检验相关病变的检测在 7T 时会得到改善的假设。背景。目前的临床影像技术还没有检测和无创诊断所有相关的脑部病变。 根据当前的成像方案，许多癫痫患者的脑部 MRI 均正常。 7 特斯拉时信噪比的显着增加提高了空间分辨率和组织对比度，这可能有助于提高癫痫病灶检测和表征的灵敏度和特异性。 主要假设 1) 在脑 3 T MRI 正常的癫痫亚组中，7 T MRI 可以检测到脑结构异常。 2) 在 3 T MRI 上有脑损伤的亚组中，将在 7 T MRI 上提供有关损伤​​的附加结构信息。 3) 在两个亚组中，将在发作发作区同侧的边缘系统纤维束中提供与健康成年受试者相比，体积减少。本研究的主要目标包括在 10 名对照健康志愿者和 20 名完全诊断的成人癫痫患者（10 名 3T MRI 正常，10 名 3T MRI 上有脑损伤）中采集非常高的空间分辨率 T1w、T2w 和 SWI 图像。将收集 DTI 数据并在选定的感兴趣区域进行纤维束分析。这些数据将进行定性和体积分析，以检验我们的假设。