SPORE in Gastrointestinal Cancer

胃肠癌中的孢子

• 批准号: 8096775
• 负责人: SCOTT E KERN
• 金额: $ 218.5万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-29 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8096775
• 关键词: SPORE; Gastrointestinal; Cancer

This application for continuation of the Specialized Program of Research Excellence (SPORE) in Gastrointestinal Cancer at the Johns Hopkins Medical Institutions supports a highly interactive, multidisciplinary, and inter-institutional program. Seven research projects within three research programs, four cores, a career development and a research developmental program are proposed to extend our translational research in colorectal and pancreatic cancer. Research Program 1: Fundamentals for individualizing patient management (Project 1A, Early detection of human colorectal and pancreatic cancer, Drs. Kinzler and Giardiello; 1B, Pharmacodiagnostics through molecular clues, Drs. Kern and Laheru). Program 2: Developing and understanding novel therapeutics (2A, Antigen-specific monitoring and therapy in pancreatic Ca, Drs. Jaffee and Laheru; 2B, Optimizing and monitoring C. novvi therapy of metastatic colorectal Ca, Drs. Zhou and Diaz). Program 3: Managing and identifying pancreatic neoplasia in the curable stage (3A, Markers for risk in familial pancreatic cancer Hruban, Klein, and Goggins; 3B, Screening markers for persons with high pancreatic cancer susceptibility, Drs. Goggins and Hruban; 3C, Fundamentals of early and variant pancreatic neoplasia, Drs. Maitra, Kern, and Hruban). The cores support the research programs (Core 1, Administration and Communication, Dr. Scott Kern; 2, Human Tissue Research and Logistics, Dr. Ralph Hruban; 3, Familial Cancer Registries, Dr. Frank Giardiello; 4, Statistics/Bioinformatics, Dr. Steven Goodman. The Career Development Program (Dr. Scott Kern) aids the emergence of new investigators and the Research Developmental Program (Dr. Bert Vogelstein) provides rapid funding of innovative directions.

此申请继续约翰霍普金斯大学医疗机构胃肠癌卓越研究专业计划 (SPORE)，支持高度互动、多学科和跨机构计划。提议在三个研究计划、四个核心、一个职业发展和一个研究发展计划中开展七个研究项目，以扩展我们在结直肠癌和胰腺癌方面的转化研究。 研究计划 1：个体化患者管理的基础知识（项目 1A，人类结直肠癌和胰腺癌的早期检测，Kinzler 和 Giardiello 博士；1B，通过分子线索进行药物诊断，Kern 和 Laheru 博士）。计划 2：开发和了解新疗法（2A，Jaffee 和 Laheru 博士对胰腺 Ca 进行抗原特异性监测和治疗；2B，优化和监测转移性结直肠 Ca 的 C. novvi 治疗，Zhou 博士和 Diaz 博士）。计划 3：管理和识别可治愈阶段的胰腺肿瘤（3A，家族性胰腺癌风险标记物，Hruban、Klein 和 Goggins；3B，高胰腺癌易感性人群的筛查标记物，Goggins 和 Hruban 博士；3C，基础知识早期和变异性胰腺肿瘤，Maitra、Kern 和 Hruban 博士）。 这些核心支持研究计划（核心 1，管理和沟通，Scott Kern 博士；2，人体组织研究和物流，Ralph Hruban 博士；3，家族癌症登记处，Frank Giardiello 博士；4，统计/生物信息学，Dr.史蒂文·古德曼。 职业发展计划（斯科特·科恩博士）帮助新研究人员的出现，研究发展计划（伯特·沃格尔斯坦博士）为创新方向提供快速资助。