Vanderbilt-Ingram Cancer Center SPORE in Gastrointestinal Cancer

范德比尔特-英格拉姆癌症中心 SPORE 在胃肠道癌症中的应用

• 批准号: 10443606
• 负责人: Robert J. Coffey
• 金额: $ 228.76万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-09 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10443606
• 关键词: Administrator; Advocate; Bioinformatics; Biometry; Cancer Center; Cancer Etiology; Cells; Cessation of life; Clinical Investigator; Collaborations; Colorectal Cancer; Consultations; Development; Environment; Epidermal Growth Factor Receptor; Funding; Glutamine; Human; International; Malignant neoplasm of gastrointestinal tract; Metabolism; Mus; National Cancer Institute; Pathology; Patient advocacy; Patients; Pharmaceutical Preparations; Pharmacologic Substance; Process; Productivity; Research; Research Personnel; Resources; Scientist; Seasons; Talents; The Vanderbilt-Ingram Cancer Center at the Vanderbilt University; Tissues; United States; animal imaging; base; cancer stem cell; career; drug discovery; drug resource; human imaging; molecular imaging; new technology; recruit; success; therapeutic target; translational research program; tumor

PROJECT SUMMARY/ABSTRACT: Overall This application is a new submission of the Vanderbilt-Ingram Cancer Center GI SPORE, which will focus on colorectal cancer, the second leading cause of cancer-related deaths in the United States. Our potential for success is high based on 1) productivity during the last cycle of our prior GI SPORE, 2) exceedingly strong institutional support, 3) recruitment of talented investigators to the field of GI cancer through career enhancement and developmental research funding, 4) access to unparalleled resources for drug discovery and small animal imaging, 5) a blend of young and seasoned clinical investigators and basic scientists working together in a highly collegial environment, 6) a committed group of patient advocates now organized into a patient advocacy council and 7) multiple inter-SPORE, pharmaceutical, national and international horizontal and vertical collaborations. We propose three projects and three supporting cores. Projects Cores 1: Interrogating Distinct Tumor-Initiating Cells in CRC 1: Tissue Pathology and Cellular Analysis 2: Targeting Glutamine Metabolism to Enhance EGFR 2: Mouse and Human Molecular Imaging Blockade in Wild-Type RAS CRC 3: Targeting MYC in CRC 3: Biostatistics and Bioinformatics

项目概要/摘要：总体 该申请是范德比尔特-英格拉姆癌症中心 GI SPORE 提交的新申请，重点关注 结直肠癌是美国癌症相关死亡的第二大原因。我们的潜力 成功率很高，基于 1) 我们之前 GI SPORE 的最后一个周期的生产力，2) 非常强大 机构支持，3）通过职业提升招募有才华的研究人员进入胃肠道癌症领域 和发展研究经费，4) 获得无与伦比的药物发现和小动物资源 成像，5）年轻而经验丰富的临床研究人员和基础科学家在高度合作的环境中合作 学院环境，6) 一群忠诚的患者倡导者现在组织成患者倡导委员会 7) 多个 SPORE 间、制药、国家和国际横向和纵向合作。 我们提出了三个项目和三个支持核心。 项目核心 1：研究 CRC 中不同的肿瘤起始细胞 1：组织病理学和细胞分析 2：靶向谷氨酰胺代谢以增强 EGFR 2：小鼠和人类分子成像 野生型 RAS CRC 的封锁 3：CRC 中的靶向 MYC 3：生物统计学和生物信息学