TMRNA MEDIATED TAGGING AND PROTEIN DEGRADATION

TRNA 介导的标记和蛋白质降解

• 批准号: 8361644
• 负责人: Robert T Sauer
• 金额: $ 0.11万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361644
• 关键词: Adaptor Signaling Protein; Funding; Grant; Mediating; Molecular; National Center for Research Resources; Peptide Hydrolases; Principal Investigator; Research; Research Infrastructure; Resources; Signal Transduction; Source; United States National Institutes of Health; cost; protein aminoacid sequence; protein degradation; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We are determining mechanisms by which peptide sequences and adaptor proteins target proteins for degradation by bacterial proteases and elucidating the molecular signals and mechanisms that regulate allosteric PDZ-proteases.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 我们正在确定肽序列和接头蛋白靶向蛋白质被细菌蛋白酶降解的机制，并阐明调节变构 PDZ 蛋白酶的分子信号和机制。