STRUCTURAL STUDIES OF RECEPTOR ACTIVATION

受体激活的结构研究

• 批准号: 8361659
• 负责人: ANDREW B HERR
• 金额: $ 0.55万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361659
• 关键词: Adhesions; Antibodies; Cell Adhesion; Funding; Grant; IgA receptor; Immunoglobulin A; Immunology; Laboratory Study; Mediating; Microbial Biofilms; National Center for Research Resources; Pathogenesis; Platelet Activation; Principal Investigator; Proteins; Receptor Activation; Research; Research Infrastructure; Resources; Source; Thrombosis; United States National Institutes of Health; Work; cost; inhibitor/antagonist; receptor; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. My laboratory studies mechanisms of receptor activation and cellular adhesion related to immunology, thrombosis, and bacterial pathogenesis. In particular, we are working on: 1) interactions between IgA antibodies and IgA receptors, 2) receptor-mediated platelet activation and thrombosis inhibitors, 3) protein-dependent intercellular adhesion in staphylococcal biofilms.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 我的实验室研究与免疫学、血栓形成和细菌发病机制相关的受体激活和细胞粘附机制。 我们特别致力于：1) IgA 抗体和 IgA 受体之间的相互作用，2) 受体介导的血小板活化和血栓形成抑制剂，3) 葡萄球菌生物膜中蛋白质依赖性细胞间粘附。