SIMULATION OF ELECTRIC STIMULATION FOR BONE GROWTH

骨骼生长的电刺激模拟

• 批准号: 8363711
• 负责人: Rob S. MacLeod
• 金额: $ 8.88万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363711
• 关键词: Address; Amputation; Amputees; Biological; Biomedical Computing; Bone Growth; Caring; Clinical; Collaborations; Complex; Computer Simulation; Dental; Electric Stimulation; Elements; Evaluation; Finite Element Analysis; Fracture Healing; Funding; Future; Goals; Grant; Image; Imagery; Implant; In Vitro; Injury; Limb structure; Mechanics; Medical; Methods; Modality; Modeling; National Center for Research Resources; Operative Surgical Procedures; Osseointegration; Patients; Phase; Principal Investigator; Prosthesis; Rehabilitation therapy; Research; Research Infrastructure; Residual state; Resources; Safety; Scanning; Services; Source; Survival Rate; Technology; Testing; Tissues; Uncertainty; United States National Institutes of Health; Veterans; War; X-Ray Computed Tomography; base; bone; combat; computer infrastructure; cost; density; design; electric field; external ear auricle; follow-up; improved; in vivo; models and simulation; research and development; sample fixation; simulation; skeletal; success; Address; Amputation; Amputees; Biological; Biomedical Computing; Bone Growth; Caring; Clinical; Collaborations; Complex; Computer Simulation; Dental; Electric Stimulation; Elements; Evaluation; Finite Element Analysis; Fracture Healing; Funding; Future; Goals; Grant; Image; Imagery; Implant; In Vitro; Injury; Limb structure; Mechanics; Medical; Methods; Modality; Modeling; National Center for Research Resources; Operative Surgical Procedures; Osseointegration; Patients; Phase; Principal Investigator; Prosthesis; Rehabilitation therapy; Research; Research Infrastructure; Residual state; Resources; Safety; Scanning; Services; Source; Survival Rate; Technology; Testing; Tissues; Uncertainty; United States National Institutes of Health; Veterans; War; X-Ray Computed Tomography; base; bone; combat; computer infrastructure; cost; density; design; electric field; external ear auricle; follow-up; improved; in vivo; models and simulation; research and development; sample fixation; simulation; skeletal; success

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Background: Improvements in medical care and evacuation strategies on the field of combat have led to an increased number of veterans surviving disastrous war related injuries. While the improved survival rate is a medical advance, many veterans are returning from combat with amputations that require complex follow-up care, extensive rehabilitation, and expensive prosthetic services. Osseointegration is a surgical procedure that provides direct skeletal attachment between an implant and host tissue with proven success in dental, auricle, and transfemoral implants. However, one challenge with using natural biological fixation is attaining a strong skeletal interlock at the implant interface, a prerequisite for long-term implant function. Therefore, the objective of this study is to build upon the previous, clinical success of electrically induced bone growth used to augment fracture healing, and to expand this technology to improve osseointegration for amputees. Rationale: To validate the general hypothesis that electrical stimulation will increase skeletal attachment, a two-phase project has been designed that utilizes in vitro, in vivo, and in silico modalities to confirm the safety and efficacy of this technology prior to implementation in veteran and warrior amputees. The specific hypotheses for this model are founded on histological assessment, mechanical testing, and finite element analysis. Specifically, finite element-based simulation analysis of veteran and warrior amputee residual limbs imaged with computed tomography scans reveal that safe and effective densities and electric fields will be attainable at the bone-implant interface. Questions: While progress on this DBP has already been substantial, there are many additional hurdles that the Center will need to address in the future. Specific examples of these challenges include image-based modeling, uncertainty visualization, detailed simulation, and estimation accuracy. Design & Methods: The main goal of the Center collaboration with this DBP is to develop a comprehensive and validated computational infrastructure that will support the creation of patient specific models of the residual limbs of amputees to assist in the evaluation and treatment by means of osseointegration. This DBP is another example of the image-based modeling and simulation pipeline that serves as a central framework of the Center's research an development.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 背景： 战斗领域的医疗保健和疏散策略的改善已导致 越来越多的退伍军人幸免于难。而 提高的生存率是医疗进步，许多退伍军人正在战斗中返回 截肢需要复杂的后续护理，广泛的康复和 昂贵的假肢服务。骨整合是一种提供直接的手术程序 植入物和宿主组织之间的骨骼附着，在牙齿方面取得了成功的成功， 耳膜和经济植入物。但是，使用自然生物学的一个挑战 固定在植入物接口处达到强大的骨骼互锁，这是 长期植入物功能。因此，这项研究的目的是建立在 以前的电诱导骨生长的临床成功用于增加骨折 康复，并扩展这项技术以改善截肢者的骨整合。 理由： 为了验证一般的假设，即电刺激会增加骨骼 依恋是一个设计的两阶段项目，该项目利用体外，体内和 在 在退伍军人和战士截肢者中实施。该模型的特定假设 建立在组织学评估，机械测试和有限元分析的基础上。 具体而言，资深和战士截肢者基于有限元的仿真分析 用计算机断层扫描成像的残留四肢表明安全有效 在骨植入术界面可以实现密度和电场。 问题： 尽管此DBP的进度已经很大，但还有许多其他 该中心将来需要解决的障碍。这些的具体例子 挑战包括基于图像的建模，不确定性可视化，详细的模拟， 和估计准确性。 设计与方法： 与该DBP合作的中心合作的主要目标是开发全面的和 经过验证的计算基础架构将支持特定于患者的创建 截肢者残留四肢的模型，以协助通过 骨整合的手段。此DBP是基于图像的建模和 模拟管道是该中心研究的中心框架 发展。