CHARACTERIZATION AND APPLICATIONS OF SERS NANOPARTICLES

SERS纳米粒子的表征及应用

• 批准号: 8361778
• 负责人: JONATHAN A DOORN
• 金额: $ 1.12万
• 依托单位: LOS ALAMOS NAT SECTY-LOS ALAMOS NAT LAB
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361778
• 关键词: Biological Assay; Diagnostic; Event; Flow Cytometry; Funding; Grant; National Center for Research Resources; Noise; Phase; Principal Investigator; Raman Spectrum Analysis; Research; Research Infrastructure; Resolution; Resources; Signal Transduction; Sorting - Cell Movement; Source; Surface; System; United States National Institutes of Health; Work; cost; instrument; nanoparticle; particle

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Surface enhanced Raman spectroscopy (SERS) nanoparticles have distinct spectral bands that can be exploited for biomedical diagnostics. In particular, SERS particles have emerged as promising beacons for flow cytometry. Because SERS particles have distinct Raman spectra with high signal to noise, they have the potential to be used for multiplexing assays that require not only great dynamic range but also narrow spectral bandwidths to discriminate between events . We are working towards the characterization of SERS particles using flow cytometry systems developed at LANL, including the spectral, phase-sensitive and high-resolution instruments.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 表面增强的拉曼光谱法（SERS）纳米颗粒具有不同的光谱带，可用于生物医学诊断。 特别是，SERS颗粒已成为流式细胞仪的有希望的信标。 由于SERS颗粒具有不同的拉曼光谱，具有高信号到噪声，因此它们有可能用于多路复用测定法，不仅需要巨大的动态范围，而且还需要狭窄的光谱带宽以区分事件。 我们正在使用在LANL开发的流式细胞仪系统来表征SERS颗粒，包括光谱，相敏和高分辨率仪器。