CHARACTERIZATION AND APPLICATIONS OF SERS NANOPARTICLES

SERS纳米粒子的表征及应用

• 批准号: 7956797
• 负责人: JONATHAN A DOORN
• 金额: $ 1.61万
• 依托单位: LOS ALAMOS NAT SECTY-LOS ALAMOS NAT LAB
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7956797
• 关键词: Biological Assay; Computer Retrieval of Information on Scientific Projects Database; Diagnostic; Event; Flow Cytometry; Funding; Grant; Institution; Noise; Phase; Raman Spectrum Analysis; Research; Research Personnel; Resolution; Resources; Signal Transduction; Sorting - Cell Movement; Source; Spectrum Analysis; Surface; System; United States National Institutes of Health; Work; instrument; nanoparticle; particle

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Surface enhanced Raman spectroscopy (SERS) nanoparticles have distinct spectral bands that can be exploited for biomedical diagnostics. In particular, SERS particles have emerged as promising beacons for flow cytometry. Because SERS particles have distinct Raman spectra with high signal to noise, they have the potential to be used for multiplexing assays that require not only great dynamic range but also narrow spectral bandwidths to discriminate between events . We are working towards the characterization of SERS particles using flow cytometry systems developed at LANL, including the spectral, phase-sensitive and high-resolution instruments.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 表面增强的拉曼光谱法（SERS）纳米颗粒具有不同的光谱带，可用于生物医学诊断。 特别是，SERS颗粒已成为流式细胞仪的有希望的信标。 由于SERS颗粒具有不同的拉曼光谱，具有高信号到噪声，因此它们有可能用于多路复用测定法，不仅需要巨大的动态范围，而且还需要狭窄的光谱带宽以区分事件。 我们正在使用在LANL开发的流式细胞仪系统来表征SERS颗粒，包括光谱，相敏和高分辨率仪器。