MYOCARDIAL INSULIN RESISTANCE IS NOT WORSENED BY WELL-CONTROLLED HIV INFECTION

心肌胰岛素抵抗不会因 HIV 感染得到良好控制而恶化

• 批准号: 8361470
• 负责人: KEVIN E YARASHESKI
• 金额: $ 4.07万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361470
• 关键词: Echocardiography; Funding; Glucose; Grant; HIV; HIV Infections; Image; Insulin; Insulin Resistance; Left Ventricular Dysfunction; Left Ventricular Function; Mass Spectrum Analysis; Metabolic; Metabolism; Methods; Myocardial; Myocardial Ischemia; National Center for Research Resources; Palmitates; Peripheral; Positron-Emission Tomography; Principal Investigator; Research; Research Infrastructure; Resources; Risk; Serum; Source; Tracer; United States National Institutes of Health; biomedical resource; cost; fatty acid metabolism; fatty acid oxidation; men

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The relationship between insulin resistance and increased risk for myocardial ischemia and left ventricular (LV) dysfunction in HIV+ men with peripheral metabolic complications (MC) are established; however the independent effects of MC and HIV infection on myocardial substrate metabolism and their relationship to LV dysfunction are unknown. Objective: To quantify myocardial glucose and fatty acid metabolism and examine the relationship to LV function in HIV+ and HIV-negative men with and without MC. Methods: In 23 HIV+ men with MC+ (HIV+/MC+, 42¿6 yrs), 15 HIV+ men without MC (HIV+/MC-, 41¿6 yrs), 9 HIV-negative men with MC (HIV-/MC+, 33¿5 yrs), and 22 HIV-negative men without MC (HIV-/MC-, 25¿6 yrs), myocardial glucose utilization (GLUT), utilization/serum insulin (GLUT/INS), and fatty acid oxidation and utilization were quantified using 11C glucose, 11C palmitate - and 15O-tracers and myocardial positron emission tomography (PET) imaging. LV function was quantified using echocardiography.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 建立了胰岛素抵抗与心肌缺血的风险增加与患有外周代谢并发症（MC）的HIV+男性左心室（LV）功能障碍之间的关系；但是，MC和HIV感染对心肌底物代谢及其与LV功能障碍的关系的独立影响尚不清楚。目的：量化心肌葡萄糖和脂肪酸代谢，并检查HIV+和HIV阴性男性和没有MC的HIV阴性男性与LV功能的关系。方法：在23名HIV+MC+的男性中（HIV+/MC+，42€6年），15 HIV+没有MC的男性（HIV+/MC-，41€6年），9名HIV阴性男性患有MC（HIV-/MC+，33 Yrs）和22 HIV hiv hiv hiv的男性，没有MC（HIV-MC-MC） （GLUT）使用11C葡萄糖，11C棕榈酸酯和15o -Tracers以及心肌正电子发射断层扫描（PET）成像对（GLUT），利用率/血清胰岛素（GLUT/INS）以及脂肪酸氧化和利用进行了定量。使用超声心动图定量LV功能。