HIV-PROTEASE INHIBITORS SUPPRESS SKELETAL MUSCLE FATTY ACID OXIDATION

HIV 蛋白酶抑制剂抑制骨骼肌脂肪酸氧化

• 批准号: 8361453
• 负责人: SASANKA RAMANADHAM
• 金额: $ 1.47万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361453
• 关键词: Fatty Acids; Funding; Grant; HIV; Hepatic; Highly Active Antiretroviral Therapy; Infection; Insulin Resistance; Intramuscular; Lipids; Lipolysis; Mass Spectrum Analysis; National Center for Research Resources; Principal Investigator; Protease Inhibitor; Research; Research Infrastructure; Resources; Skeletal Muscle; Source; United States National Institutes of Health; base; biomedical resource; cost; fatty acid oxidation; fatty acid transport; lipid metabolism; oxidation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Infection with human immunodeficiency virus (HIV) and treatment with HIV-protease inhibitor (PI)-based highly active antiretroviral therapies (HAART) is associated with dysregulated fatty acid and lipid metabolism. Enhanced lipolysis, increased circulating fatty acid levels, and hepatic and intramuscular lipid accumulation appear to contribute to insulin resistance in HIV-infected people treated with PI-based HAART. However, it is unclear whether currently prescribed HIV-PIs directly alter skeletal muscle fatty acid transport, oxidation, and storage.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 通过人类免疫缺陷病毒（HIV）感染和用HIV-蛋白酶抑制剂（PI）的高度活性抗逆转录病毒疗法（HAART）感染与失调的脂肪酸和脂质代谢有关。增强的脂解，循环脂肪酸水平增加，肝内脂质积累似乎有助于受PI基于HAART治疗的HIV感染者的胰岛素抵抗。但是，目前尚不清楚当前处方的HIV-PI是否直接改变骨骼肌肉脂肪酸的转运，氧化和储存。