ISLET COMPLEX LIPID IN GROUP VIA CALCIUM INDEPENDENT PHOSPHOLIPASE A2 IN B CELL

B 细胞中通过钙独立磷脂酶 A2 组中的胰岛复合脂质

• 批准号: 7355207
• 负责人: SASANKA RAMANADHAM
• 金额: $ 0.94万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7355207
• 关键词: ISLET; COMPLEX; LIPID; GROUP; VIA

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The group VIA phospholipase A2 designated iPLA2B does not require calcium for activation, is stimulated by ATP, and is sensitive to inhibition by a bromoenol lactone suicide substrate (BEL). Several potential functions have been proposed for iPLA2B. Detailed characterization of the iPLA2B protein level reveals that b-cells express multiple isoforms of the enzyme, and our studies involve the hypothesis that different isoforms have different.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。该组通过磷脂酶A2指定的IPLA2B不需要钙即可激活，因此受ATP刺激，并且对溴烯醇内酯自杀底物（BEL）对抑制作用敏感。 IPLA2B提出了几种潜在功能。 IPLA2B蛋白水平的详细表征表明，B细胞表达酶的多种同工型，我们的研究涉及以下假设：不同的同工型具有不同的。