STRUCTURAL STUDY OF BACTERIAL TOXINS

细菌毒素的结构研究

• 批准号: 8362107
• 负责人: IRIMPAN I MATHEWS
• 金额: $ 0.38万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362107
• 关键词: Bacterial Toxins; Funding; Grant; National Center for Research Resources; Pharmaceutical Preparations; Principal Investigator; Radiation; Research; Research Infrastructure; Resources; Safety; Source; Toxin; United States National Institutes of Health; Work; cost; prevent; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Bacterial toxins cause various pathological effects. The current study proposes to investigate the effect of few known bacterial toxins. The primary aim is to develop potential drugs to treat or prevent toxin related illness. The preliminary studies have generated few potential targets and the structural study is aimed at understanding the mechanism. Due to safety concern, we will be working on genetically modified forms which are inactivated and nontoxic.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 细菌毒素会引起各种病理作用。目前的研究打算调查几种已知细菌毒素的影响。主要目的是开发潜在的药物来治疗或预防毒素相关疾病。初步研究产生的潜在目标很少，结构研究旨在了解其机制。出于安全考虑，我们将致力于灭活且无毒的转基因形式。