Oklahoma Center for Microbial Pathogenesis and Immunity

俄克拉荷马州微生物发病机制和免疫中心

• 批准号: 10554351
• 负责人: Jimmy D. Ballard
• 金额: $ 215.74万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10554351
• 关键词: Acceleration; Address; Area; Bacterial Infections; Bacterial Toxins; Biology; Biomedical Research; Career Mobility; Cellular Immunity; Centers of Research Excellence; Cessation of life; Collaborations; Communicable Diseases; Communities; Data; Discipline; Disease; Educational workshop; Elements; Ensure; Environment; Event; Eye Infections; Faculty; Fostering; Foundations; Funding; Future; Genetic; Goals; Gram-Positive Bacteria; Grant; Health; Health Sciences; Hospitals; Human; Immune response; Immune system; Immunity; Immunology; Infection; Inflammation; Infrastructure; Institution; Laboratory Research; Life; Mentors; Microbe; Microbial Biofilms; Microbiology; Mission; Modernization; Molecular; Necrotizing Enterocolitis; Oklahoma; Pathogenesis; Phase; Pilot Projects; Productivity; Program Sustainability; Regulation; Research; Research Infrastructure; Research Personnel; Research Priority; Research Project Grants; Resources; Science; Scientist; Strategic Planning; Structure; Technology; Therapeutic; Training; Translating; United States National Institutes of Health; Universities; Work; Writing; adaptive immunity; career; career development; cohort; collaborative environment; gut colonization; improved; innovation; microbial; microbiome; multidisciplinary; news; outreach; pathogen; pathogenic fungus; programs; recruit; success; symposium; transcriptome

Abstract The goal of this Phase-1 COBRE program is to develop and enhance the research infrastructure, mentoring, and collaborative environment to support five Junior Investigators in the multi-disciplinary fields of microbial pathogenesis and immunity. To achieve this goal, The Oklahoma Center for Microbial Pathogenesis and Immunity (OCMP&I) COBRE will be established and fostered as a center of excellence focused on advancing the careers of Junior Investigators studying life-threatening infectious microbes and the ways in which the immune system responds to infection. The OCMP&I COBRE will be centrally located at the University of Oklahoma Health Sciences Center, the flagship academic institution for biomedical research in Oklahoma. The OCMP&I COBRE will initially include 17 scientists engaged in microbial pathogenesis and immunity research at research-intensive institutions in Oklahoma and this network will be expanded during the Phase-1 period as the center takes form and grows. Among these 17 scientists are five outstanding and promising Junior Investigators who study fungal pathogenesis, inflammation, regulation of biofilms, and necrotizing enterocolitis. The OCMP&I and its consortium of successful senior researcher scientists will provide the intellectual input and expertise to mentor each Junior Investigator to research independence. In addition to outstanding mentoring, The OCMP&I COBRE will provide the funding and research core support needed for Junior Investigators to succeed and become long-term contributors to the microbial pathogenesis and immunity research community in Oklahoma. Intertwined with the Junior Investigator support, will be the OCMP&I COBRE's mission to address gaps in infrastructure and resources that have limited the opportunities for cutting-edge research in our state. To achieve these objectives, the OCMP&I COBRE will be guided by four overall specific aims. Specific Aim 1: Establish a thematic center to enhance research, mentoring, and infrastructure support for microbial pathogenesis and immunity research in Oklahoma, Specific Aim 2: Select and support outstanding Junior Investigators, Specific Aim 3: Expand and enhance infrastructure to support innovative and collaborative research in microbial pathogenesis and immunity in Oklahoma. Specific Aim 4: Foster a culture of collaboration and team-science by providing opportunities for frequent scholarly interactions and outreach through seminars, symposiums, workshops, and pilot projects. Key elements for the success of the center include 1) the establishment of a single, but highly facile research core, that can immediately support the first group of Junior Investigator projects and expand to meet ever- changing research needs of investigators in microbial pathogenesis and immunity, 2) up date and modernize research laboratory space where Junior Investigators can work with established investigators and benefit from daily interactions, 3) Develop a pipeline of future Junior Investigators through targeted hires and through collaboration with a network of departmental leaders on multiple campuses, 4) Utilize and capitalize on current IDeA program resources in Oklahoma, and 5) Utilize an ongoing seminar program, sponsor a new annual symposium, and support a grant-writing workshop to encourage collaborative interactions and exchange of ideas among investigators in this multi-disciplinary area of research. Collectively, this five-year Phase-1 COBRE program will establish the first center of research excellence in Oklahoma focused on microbial pathogenesis and immunity and become the central entity that accelerates research by all investigators in these fields and provides a highly-supportive path to independence for our most promising Junior Investigators.

抽象的 第一阶段 COBRE 计划的目标是发展和加强研究 基础设施、指导和协作环境，以支持五名初级研究员 微生物发病机制和免疫的多学科领域。为了实现这一目标， 俄克拉荷马州微生物发病机制和免疫中心 (OCMP&I) COBRE 将 建立并培育成为一个专注于促进青少年职业发展的卓越中心 研究人员正在研究危及生命的传染性微生物以及免疫系统的作用方式 系统对感染做出反应。 OCMP&I COBRE 将位于大学的中心 俄克拉荷马州健康科学中心，美国生物医学研究的旗舰学术机构 俄克拉荷马州。 OCMP&I COBRE 最初将包括 17 名从事微生物研究的科学家 俄克拉荷马州研究密集型机构的发病机制和免疫研究 随着中心的形成和发展，网络将在第一阶段得到扩展。 在这 17 名科学家中，有 5 名杰出且有前途的初级研究员，他们的研究 真菌发病机制、炎症、生物膜调节和坏死性小肠结肠炎。这 OCMP&I 及其成功的高级研究科学家联盟将提供 指导每个初级研究员独立研究的智力投入和专业知识。在 除了出色的指导外，OCMP&I COBRE 还将提供资金和研究 初级研究者取得成功并成为长期贡献者所需的核心支持 俄克拉荷马州的微生物发病机制和免疫研究团体。交织在一起 初级研究员的支持将是 OCMP&I COBRE 的使命，旨在解决 基础设施和资源限制了我们进行尖端研究的机会 状态。为了实现这些目标，OCMP&I COBRE 将遵循四个总体具体目标 目标。具体目标 1：建立一个主题中心，以加强研究、指导和 俄克拉荷马州微生物发病机制和免疫研究的基础设施支持，具体 目标 2：选择和支持优秀的初级研究者，具体目标 3：扩大和 加强基础设施以支持微生物的创新和合作研究 俄克拉荷马州的发病机制和免疫。具体目标 4：培养协作文化 团队科学，通过提供频繁的学术互动和外展机会 研讨会、专题讨论会、讲习班和试点项目。成功的关键要素 中心包括 1) 建立一个单一但高度便利的研究核心，可以 立即支持第一组初级研究员项目并扩大以满足永远的需求 微生物发病机制和免疫领域研究者的研究需求不断变化，2) 更新 并使研究实验室空间现代化，初级研究人员可以在其中与现有的研究人员一起工作 调查员并从日常互动中受益，3）开发未来初级人才的管道 调查人员通过有针对性的雇用以及与部门网络的合作 多个校区的领导者，4) 利用和利用当前的 IDeA 项目资源 俄克拉荷马州，以及 5) 利用正在进行的研讨会计划，赞助新的年度研讨会，以及 支持资助写作研讨会，以鼓励协作互动和思想交流 在这个多学科研究领域的研究人员中。总的来说，这五年 第一阶段 COBRE 计划将在俄克拉荷马州建立第一个卓越研究中心 专注于微生物发病机制和免疫，成为加速发展的核心实体 这些领域的所有研究人员的研究，并提供了一条高度支持的途径 我们最有前途的初级研究人员的独立性。