STUDIES OF SHEAR STRESS ON CELLS

细胞剪切应力的研究

• 批准号: 8362650
• 负责人: ELIAS BOTVINICK
• 金额: $ 2.96万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362650
• 关键词: Biotechnology; Cells; Endothelial Cells; Funding; Grant; Imaging Techniques; Lasers; Monitor; Morphology; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Rotation; Source; Stress; Testing; United States National Institutes of Health; cost; fluorescence imaging; response; shear stress

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Function and morphology of endothelial cells are regulated by shear stress. In this project a small laminar flow field will be created by rotating microparticles. Different type of microparticles will be tested for achieving a rotation rate suitable for creating a locally high shear stress. Fluorescence imaging techniques will be used for monitoring the dynamic responses of the cells to stress.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 内皮细胞的功能和形态受剪切应力调节。 在这个项目中，将通过旋转微粒创建一个小的层流场。将测试不同类型的微粒，以实现适合创建局部剪切应力的旋转速率。荧光成像技术将用于监测细胞对压力的动态响应。