CEREBRAL AUTOREGULATION OF VERY LOW BIRTH WEIGHT, PREMATURE INFANTS

极低出生体重早产儿的大脑自动调节

• 批准号: 7955329
• 负责人: Turgut Durduran
• 金额: $ 1.11万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955329
• 关键词: Affect; Blood capillaries; Blood flow; Brain Injuries; Cerebrovascular Circulation; Cerebrum; Computer Retrieval of Information on Scientific Projects Database; Diffuse; Funding; Future; Grant; Hemorrhage; Homeostasis; Infant; Injury; Institution; Lead; Low Birth Weight Infant; Magnetic Resonance; Measures; Methods; Monitor; Patients; Periventricular Leukomalacia; Population; Premature Infant; Research; Research Personnel; Resources; Risk; Source; Spectrum Analysis; Techniques; United States National Institutes of Health; Very Low Birth Weight Infant; capillary; intraventricular hemorrhage; optical imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Preterm very-low-birthweight (VLBW) infants are at significant risk of brain injury due to their immature ability to regulate cerebral blood flow (CBF). Two of the most common brain injuries affecting this patient group are intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL). The onsets of both IVH and PVL are highly dependent on changes in CBF. For example, in the case of IVH, a decrease in blood flow can cause injury to immature capillary vessels in the germinal matrix. This damage can lead to hemorrhage if flow increases in the future. This study aims to investigate whether diffuse correlation spectroscopy (DCS) could be used to measure blood flow changes in this delicate population. Because of these infants' fragile condition, there exist few methods to evaluate their CBF. None of these techniques are able to monitor continuously at the bedside.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 早产极低出生体重（VLBW）婴儿由于其​​身体原因而面临脑损伤的显着风险 调节脑血流（CBF）的能力不成熟。两种最常见的脑损伤 影响该患者群体的是脑室内出血 (IVH) 和脑室周围出血 脑白质软化症（PVL）。 IVH 和 PVL 的发作高度依赖于 CBF 的变化。 例如，在 IVH 的情况下，血流量减少可能会导致未成熟毛细血管损伤 生发基质中的血管。如果血管内的流量增加，这种损伤可能会导致出血。 未来。本研究旨在探讨漫相关光谱（DCS）是否可以用于 用于测量这一脆弱人群的血流变化。由于这些婴儿的脆弱 条件下，评估其 CBF 的方法很少。这些技术都无法 在床边持续监测。