PRE CLINICAL EVALUATION OF LASER PORT WINE THERAPY

激光葡萄酒疗法的临床前评估

• 批准号: 8362598
• 负责人: JOHN STUART NELSON
• 金额: $ 0.51万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362598
• 关键词: Biotechnology; Blood Vessels; Clinical Management; Dermis; Development; Dyes; Funding; Grant; Lasers; Light; Low-Level Laser Therapy; National Center for Research Resources; Optics; Patients; Physiologic pulse; Principal Investigator; Quantitative Evaluations; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; Wine; cost; density; dosage; malformation; pre-clinical; research clinical testing; tomography

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. PWS is a congenital, progressive vascular malformation of the dermis. The pulsed dye laser can coagulate selectively PWS by inducing microthrombus formation within the targeted blood vessels. However, most patients requires multiple treatment and only a small proportion of patients obtain 100% fading of their PWS. The objective of the proposed research is the development of Optical Doppler Tomography (ODT) for application in the clinical management of patients with PWS by providing a semi-quantitative evaluation of the efficiency of pulsed laser therapy. The information provided by ODT on the depth, size, and density of the vasculatures will be used to select optimal pulse duration and light dosage of laser exposure for PWS therapy.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 PWS 是一种先天性进行性真皮血管畸形。 脉冲染料激光可以通过诱导目标血管内微血栓形成来选择性凝固 PWS。然而，大多数患者需要多次治疗，只有一小部分患者的 PWS 100% 消退。 拟议研究的目的是开发光学多普勒断层扫描 (ODT)，通过对脉冲激光治疗的效率进行半定量评估，将其应用于 PWS 患者的临床管理。 ODT 提供的有关脉管系统深度、大小和密度的信息将用于选择 PWS 治疗的激光照射的最佳脉冲持续时间和光剂量。