PRE CLINICAL EVALUATION OF LASER PORT WINE THERAPY

激光葡萄酒疗法的临床前评估

• 批准号: 7954753
• 负责人: JOHN STUART NELSON
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7954753
• 关键词: Biotechnology; Blood Vessels; Clinical Management; Computer Retrieval of Information on Scientific Projects Database; Dermis; Development; Dyes; Funding; Grant; Institution; Lasers; Light; Low-Level Laser Therapy; Optics; Patients; Physiologic pulse; Quantitative Evaluations; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Wine; density; dosage; malformation; pre-clinical; research clinical testing; tomography

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. PWS is a congenital, progressive vascular malformation of the dermis. The pulsed dye laser can coagulate selectively PWS by inducing microthrombus formation within the targeted blood vessels. However, most patients requires multiple treatment and only a small proportion of patients obtain 100% fading of their PWS. The objective of the proposed research is the development of Optical Doppler Tomography (ODT) for application in the clinical management of patients with PWS by providing a semi-quantitative evaluation of the efficiency of pulsed laser therapy. The information provided by ODT on the depth, size, and density of the vasculatures will be used to select optimal pulse duration and light dosage of laser exposure for PWS therapy.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 PWS 是一种先天性进行性真皮血管畸形。 脉冲染料激光可以通过诱导目标血管内微血栓形成来选择性凝固 PWS。然而，大多数患者需要多次治疗，只有一小部分患者的 PWS 100% 消退。 拟议研究的目的是开发光学多普勒断层扫描 (ODT)，通过对脉冲激光治疗的效率进行半定量评估，将其应用于 PWS 患者的临床管理。 ODT 提供的有关脉管系统深度、大小和密度的信息将用于选择 PWS 治疗的激光照射的最佳脉冲持续时间和光剂量。