MULTIPLEXED ANALYSIS OF INFLUENZA VIRUS TYPE, SUB-TYPE, & RECEPTOR SPECIFICITY

流感病毒类型、亚型、

• 批准号: 8361855
• 负责人: ROBERT J WOODS
• 金额: $ 0.18万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361855
• 关键词: Antibodies; Avian Influenza; Basic Science; Biological Assay; Flu virus; Funding; Grant; Human; Immunoassay; Measurement; National Center for Research Resources; Phenotype; Principal Investigator; Research; Research Infrastructure; Resources; Source; Specificity; United States National Institutes of Health; Virus; base; carbohydrate receptor; cost; influenzavirus; preference; receptor; receptor binding; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In order to facilitate the characterization of flu virus for both basic research and surveillance, we have developed a multiplexed microparticle-based assay for simultaneous antibody-based strain typing and sub-typing, as well characterization of carbohydrate receptor binding preference. The combination of immunoassay-based virus sub-typing and receptor binding phenotype measurements provides an important new tool in tracking the adaptation of avian flu strains to human hosts.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 为了促进基础研究和监测流感病毒的表征，我们开发了一种基于多重微粒的基于多粒子的测定法，用于同时基于抗体的菌株型和亚型，以及碳水化合物受体结合偏好的很好表征。基于免疫测定的病毒亚型和受体结合表型测量的组合为跟踪禽流感菌株对人宿主的适应性提供了重要的新工具。