CHARACTERIZING THE 3D PROPERTIES OF POLY(NEU5AC) VS POLY(NEU5GC) POLYMERS

表征 POLY(NEU5AC) 与 POLY(NEU5GC) 聚合物的 3D 特性

• 批准号: 8361834
• 负责人: ROBERT J WOODS
• 金额: $ 0.18万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361834
• 关键词: Biological; Chemicals; Data; Funding; Future; Grant; Length; Molecular Conformation; National Center for Research Resources; Polymers; Principal Investigator; Property; Research; Research Infrastructure; Resources; Shapes; Source; United States National Institutes of Health; cost; molecular dynamics

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Experimental data, NMR, is available which shows that Neu5Ac and Neu5Gc have different 3D conformations. Aside from chemical differences between Neu5Ac and Neu5Gc, these 3D structural differences may also provide a mechanism for differences in biological recognition. Various polymers of Neu5Ac and Neu5Gc will be compared using Molecular Dynamics (MD) simulations to determine the 3D shapes of the polymers and comparisons will be made to experimental data of identical polymer lengths. Additionally, polymers without experimental data will be studied to provide predictive data for future experimental comparisons.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 实验数据NMR可用，表明NEU5AC和NEU5GC具有不同的3D构象。 除了NEU5AC和NEU5GC之间的化学差异外，这些3D结构差异还可能为生物学识别的差异提供机制。 将使用分子动力学（MD）模拟比较NEU5AC和NEU5GC的各种聚合物，以确定聚合物的3D形状，并将比较与相同聚合物长度的实验数据进行比较。 此外，将研究没有实验数据的聚合物，以提供预测数据以进行未来的实验比较。