CHARACTERIZE THE FUNCTION OF PROTEIN TYROSINE PHOSPHATASE PTPMT1 IN MITOCHONDRIA

表征蛋白质酪氨酸磷酸酶 PTPMT1 在线粒体中的功能

• 批准号: 8361936
• 负责人: JACK E DIXON
• 金额: $ 3.7万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361936
• 关键词: Electron Microscopy; Funding; Grant; Image Analysis; Membrane; Mitochondria; National Center for Research Resources; Principal Investigator; Protein Tyrosine Phosphatase; Research; Research Infrastructure; Research Personnel; Resources; Source; United States National Institutes of Health; Work; cost; electron tomography

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. PTPMT1 was the first protein tyrosine phosphatase found to localize to the inner membrane of mitochondria. Our recent work has suggested that PTPMT1 is required for the integrity and optimal function of mitochondria. We collaborate with NCMIR whose researchers perform electron microscopy and electron tomography to further characterize the function of PTPMT1 in mitochondria.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 PTPMT1是发现位于线粒体内膜的第一个蛋白酪氨酸磷酸酶。我们最近的工作表明，PTPMT1是线粒体的完整性和最佳功能所必需的。我们与NCMIR合作，其研究人员执行电子显微镜和电子断层扫描，以进一步表征PTPMT1在线粒体中的功能。