IN VIVO 3D LUNG IMAGING WITH HYPERPOLARIZED 129XENON

使用超极化 129XENON 进行体内 3D 肺部成像

• 批准号: 8363180
• 负责人: ZACKARY I CLEVELAND
• 金额: $ 0.61万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363180
• 关键词: Breathing; Environmental air flow; Funding; Gases; Grant; Image; Lung; Magnetic Resonance Imaging; Methods; Microscopy; National Center for Research Resources; Phase; Principal Investigator; Rattus; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; cost; in vivo; lung imaging; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The purpose of this study is to develop a robust method for 3D hyperpolarized (HP) 129Xe MR imaging of the rat lung. In this project, HP 129Xe will be delivered by inhalation, and both dissolved and gas-phase HP 129Xe will be imaged. Methods will be developed to co-register the dissolved and ventilation images and provide a novel method of detecting pathological changes in the lung.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 这项研究的目的是为大鼠肺的3D超极化（HP）129XE MR成像开发一种可靠的方法。在该项目中，HP 129XE将通过吸入提供，并且将成像溶解和气相HP 129XE。将开发方法来共同注册溶解和通风图像，并提供一种检测肺中病理变化的新方法。