VENTILATION DEFECTS IN LUNG INFLAMMATORY MODELS USING HYPERPOLARIZED 3HE MRI

使用超极化 3HE MRI 观察肺部炎症模型中的通气缺陷

• 批准号: 8363158
• 负责人: abraham thomas
• 金额: $ 1.23万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363158
• 关键词: Affect; Animals; Asthma; Defect; Disease; Environmental air flow; Funding; Global Change; Grant; Inflammatory; Lung; Magnetic Resonance Imaging; Medical Students; Mentors; Methods; Microscopy; Modeling; National Center for Research Resources; Principal Investigator; Process; Research; Research Infrastructure; Resources; Respiratory physiology; Rotation; Source; Techniques; United States National Institutes of Health; constriction; cost; in vivo; regional difference

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. 3rd year medical student - doing his research rotation with mentor, Dr. Bastiaan Driehuys Research in asthmatics and small animal asthma models has indicated that airway constriction leads to regional differences in lung ventilation, which can manifest as ventilation defects. Though the defects are not uniformly distributed throughout the lung, current in vivo methods for assessment of lung function only allow for assessment of global changes. Therefore, these techniques are unable to characterize changes in regions of the lung that are most affected by the disease process.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 三年级医学生 - 与导师 Bastiaan Driehuys 博士一起进行研究轮转 对哮喘患者和小动物哮喘模型的研究表明，气道收缩会导致肺通气的区域差异，这可能表现为通气缺陷。尽管缺陷并未均匀分布在整个肺部，但目前评估肺功能的体内方法仅允许评估整体变化。因此，这些技术无法表征受疾病过程影响最大的肺部区域的变化。