VENTILATION DEFECTS IN LUNG INFLAMMATORY MODELS USING HYPERPOLARIZED 3HE MRI

使用超极化 3HE MRI 观察肺部炎症模型中的通气缺陷

• 批准号: 8171577
• 负责人: abraham thomas
• 金额: $ 1.09万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171577
• 关键词: Affect; Animals; Asthma; Computer Retrieval of Information on Scientific Projects Database; Defect; Disease; Environmental air flow; Funding; Global Change; Grant; Inflammatory; Institution; Lung; Medical Students; Mentors; Methods; Modeling; Process; Research; Research Personnel; Resources; Respiratory physiology; Rotation; Source; Techniques; United States National Institutes of Health; constriction; in vivo; regional difference

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 3rd year medical student - doing his research rotation with mentor, Dr. Bastiaan Driehuys Research in asthmatics and small animal asthma models has indicated that airway constriction leads to regional differences in lung ventilation, which can manifest as ventilation defects. Though the defects are not uniformly distributed throughout the lung, current in vivo methods for assessment of lung function only allow for assessment of global changes. Therefore, these techniques are unable to characterize changes in regions of the lung that are most affected by the disease process.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 三年级医学生 - 与导师 Bastiaan Driehuys 博士一起进行研究轮转 对哮喘患者和小动物哮喘模型的研究表明，气道收缩会导致肺通气的区域差异，这可能表现为通气缺陷。尽管缺陷并未均匀分布在整个肺部，但目前评估肺功能的体内方法仅允许评估整体变化。因此，这些技术无法表征受疾病过程影响最大的肺部区域的变化。