MICRO-CT-BASED PERFUSION IMAGING IN SMALL ANIMALS

基于微型 CT 的小动物灌注成像

• 批准号: 8363172
• 负责人: Christian Tudorel Badea
• 金额: $ 1.84万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363172
• 关键词: Address; Animals; Contrast Media; Dose; Funding; Grant; Image; Imaging Techniques; Injection of therapeutic agent; Magnetic Resonance; Measurement; Medical Imaging; Microscopy; Morphologic artifacts; National Center for Research Resources; Perfusion; Principal Investigator; Process; Radiation; Research; Research Infrastructure; Resolution; Resources; Rotation; Sampling; Series; Solutions; Source; System; Time; United States National Institutes of Health; Variant; Weight; Work; base; cost; density; detector; in vivo; novel; reconstruction

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In vivo measurements of perfusion presents a challenge to existing small animal imaging techniques such as magnetic resonance microscopy (MRM), microCT, microPET, and microSPECT, due to combined requirements for high spatial and temporal resolution. In Micro-CT perfusion to these requirements are added the radiation dose restrictions. In sampling, we have addressed these issues by using a dual source/detector Micro-CT system, and the novel paradigm that the same time density curves can be reproduced in a number of consecutive injections of ¿L volumes of contrast at a series of different angles of rotation. The high temporal resolution requirements and total volume of contrast agent used imposes undersampling which complicates the reconstruction process, since it causes significant streaking artifacts. We demonstrate an approach using a combined static micro-CT set with dynamic but angularly undersampled acquisitions. We provide an iterative reconstruction solution that uses the well sampled static micro-CT set as a prior. A sparseness prior regularized weighted l2 norm optimization is proposed to mitigate streaking artifacts based on the fact that most medical images are compressible. A prior Total Variation (TV) is implemented in this work as the regularizer for its simplicity.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 由于对高空间和临时分辨率的组合要求，灌注的体内测量对现有的小动物成像技术（例如磁共振显微镜（MRM），MIDROCT，MICROPET和MICROPECT）提出了挑战。在对这些需求的微型CT灌注中，添加了辐射剂量限制。在采样中，我们通过使用双源/检测器微CT系统解决了这些问题，以及新的范式，即可以在一系列不同角度的一系列不同角度以对比度的连续注射相同的时间密度曲线可以重现同一时间密度曲线。高度临时分辨率要求和对比剂的总数施加了使重建过程复杂化的，因为它会引起大量的条纹伪像。我们展示了一种使用动态但棱角不足的采集的组合静态微CT集。我们提供了一种迭代重建解决方案，该解决方案将采样精心采样的静态Micro-CT集作为先验。提出了稀疏性，提出了基于大多数医学图像相处的事实，提出了调节伪影的稀疏性。这项工作中实现了先前的总变化（TV），以简单起见。