COBRE: UNE MED CTR: CORE B: MOUSE GENOME ENGINEERING

COBRE：UNE MED CTR：核心 B：小鼠基因组工程

• 批准号: 8360391
• 负责人: CHANNABASAVAIAH GURUMURTHY
• 金额: $ 6.42万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360391
• 关键词: Animal Model; Biomedical Research; Centers of Research Excellence; Development; Extramural Activities; Fostering; Funding; Future; Generations; Genes; Genome engineering; Goals; Grant; Healthcare; Human; Institution; Knockout Mice; Molecular Biology; Molecular Profiling; Mus; National Center for Research Resources; Principal Investigator; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Resources; Services; Site; Source; System; Transgenic Mice; United States National Institutes of Health; boys; cost; experience; mouse genome; mouse model; neurosurgery; research study; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. One goal of this COBRE proposal is to establish the triangle UNMC-Creighton-Boys Town NRH as a recognized Center of Research Excellence in Neurosensory Development. With the commitment of all three institutions to human health care, the mouse will be the paramount model organism for future biomedical research on this topic. The presence and availability of a Mouse Core will, therefore, not only benefit the initial COBRE Investigators through the on-site establishment of the pertinent mouse models, but will serve as an essential recruiting tool once the initial COBRE Investigators will rotate off and new Investigators will be brought aboard. We anticipate that such recruits will also focus on the mouse, use genetically manipulated mice to advance their research. In particular, junior Investigators with limited experience with mice would greatly benefit from Mouse Core support services. Furthermore, we expect that the expression profiling experiments of several projects of this proposal will yield results that merit the generation of new transgenic and knockout mouse models for the respective genes in order to study their function in neurosensory development. We are therefore convinced that the availability of a Mouse Core will significantly enhance the competitiveness of new applications for extramural funding that are fostered by this COBRE proposal.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 这个毛刺提案的目标之一是建立三角形杂物，以置身为creighton-boys town nrh作为一个 公认的神经感觉发展卓越研究中心。以所有人的承诺 三个用于人类医疗保健的机构，鼠标将成为未来的最重要模型生物 关于此主题的生物医学研究。因此，鼠标核心的存在和可用性将不是 仅通过现场建立相关小鼠的最初毛to研究者受益 模型，但一旦最初的毛线调查人员旋转，将成为必不可少的招聘工具 新的调查人员将被带到船上。我们预计此类新兵也将关注 鼠标，使用遗传操纵的小鼠来推进其研究。特别是初级调查员 凭借小鼠的经验有限，将从鼠标核心支持服务中受益匪浅。 此外，我们期望该提案的几个项目的表达分析实验 将产生结果，值得生成新的转基因和基因敲除鼠标模型 各自的基因是为了研究其在神经感觉发育中的功能。因此，我们是 坚信鼠标核心的可用性将显着提高新的竞争力 该鞋垫提案促进的校外资金申请。