ATN 048: CORRELATES OF HBV-SPECIFIC B CELL MEMORY FOLLOWING VACCINATION IN HIV

ATN 048：HIV 疫苗接种后 HBV 特异性 B 细胞记忆的相关性

• 批准号: 7951110
• 负责人: LAWRENCE James D'ANGELO
• 金额: $ 0.28万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951110
• 关键词: Adolescent; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Evaluation; Funding; Grant; HIV; Hepatitis B Surface Antigens; Hepatitis B Virus; Immune response; Immunization; Institution; Laboratories; Memory B-Lymphocyte; Research; Research Personnel; Resources; Serological; Source; United States National Institutes of Health; Vaccination; base

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is an exploratory laboratory-based evaluation of cellular immune response to immunization with hepatitis B surface antigen in HIV-infected and HIV-uninfected adolescents. This is a substudy of ATN 024 and ATN 025. This substudy will compare cellular immune response in responders and nonresponders to immunization and also evaluate the relationship of these factors to the persistence of known correlates of serologic protection for the hepatitis B virus.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这是一项基于实验室的探索性评估，评估感染艾滋病毒和未感染艾滋病毒的青少年对乙型肝炎表面抗原免疫的细胞免疫反应。这是 ATN 024 和 ATN 025 的子研究。该子研究将比较免疫反应者和无反应者的细胞免疫反应，并评估这些因素与乙型肝炎病毒血清学保护的已知相关性的持久性的关系。