OUTCOME MEASUREMENT OF MTBI IN CHILDREN AND ADOLESCENTS

儿童和青少年 MTBI 的结果测量

• 批准号: 8167301
• 负责人: GERARD A. GIOIA
• 金额: $ 0.05万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-20 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167301
• 关键词: 18 year old; Adolescent; Age; Alleles; Area; Back; Behavioral; Child; Childhood; Childhood Injury; Clinical; Complex; Computer Retrieval of Information on Scientific Projects Database; Development; Education; Funding; Gene Frequency; Genes; Genetic; Genetic Polymorphism; Grant; Institution; Link; Measurement; Measures; Medical center; Neurocognitive; Outcome; Outcome Measure; Phase; Process; Protocols documentation; Psychometrics; Recovery; Research; Research Personnel; Resources; Sample Size; Sensitivity and Specificity; Short-Term Memory; Source; Testing; Traumatic Brain Injury; United States National Institutes of Health; Universities; Validation; interest; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although mild traumatic brain injury (mTBI) is among the most common injuries in children, little systemic research has been done regarding the recovery process and long-term functional sequelae of children following mTBI, including the influence of genetic factors. Linking polymorphic alleles to neurocognitive outcome is one strategy to determine if certain genes contribute to recovery after mTBI. However, allelic polymorphism studies require well-defined and validated outcome measures and sample sizes appropriate for the frequency of alleles of interest. This protocol describes the Phase 1, the piloting phase, of a 4-phase, 6-year-multi-center collaborative research study between Children's National Medical Center, the Department of Education-Kaua'i Complex Area, University of Pittsburgh Medical Center, A.T. Still University and Dartmouth Hitchcock Medical Center. The aim of Phase 1, which has already been completed, was the initial development and adaptation of the three principal tests of the mTBI battery for the pediatric age range (5-18 years) - ImPACT, the BRIEF, and the N-back working memory measure. The specific aim of Phase 2 is the psychometric development of the tests with the mTBI battery including norming, test-retest reliability, and concurrent validity across the 5-18 year age range. The specific aim of Phase 3 is clinical validation, i.e., to establish the sensitivity and specificity of the mTBI battery to detect neruocognitive and behavioral changes in children with mTBI.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 尽管轻度创伤性脑损伤（mTBI）是儿童最常见的损伤之一，但关于mTBI后儿童的恢复过程和长期功能后遗症（包括遗传因素的影响）的系统研究却很少。将多态性等位基因与神经认知结果联系起来是确定某些基因是否有助于 mTBI 后恢复的一种策略。然而，等位基因多态性研究需要明确且经过验证的结果测量以及适合感兴趣等位基因频率的样本量。该协议描述了国家儿童医学中心、考爱岛综合区教育部、匹兹堡大学医学中心、在。斯蒂尔大学和达特茅斯希区柯克医学中心。已经完成的第一阶段的目标是针对儿科年龄范围（5-18 岁）的 mTBI 电池的三个主要测试进行初步开发和调整 - ImPACT、BRIEF 和 N-back 工作记忆测量。 第二阶段的具体目标是使用 mTBI 电池进行心理测量开发，包括标准化、重测可靠性以及 5-18 岁年龄范围内的并发有效性。第三阶段的具体目标是临床验证，即建立 mTBI 电池检测 mTBI 儿童神经认知和行为变化的敏感性和特异性。