TREAMENT OF EARLY AGE MANIA (TEAM)

早期躁狂症的治疗（团队）

• 批准号: 7951083
• 负责人: PARAMJIT T. JOSHI
• 金额: $ 3.32万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951083
• 关键词: 15 year old; Age; Childhood; Clinical Research; Complex; Computer Retrieval of Information on Scientific Projects Database; DSM-IV; Disease; Effectiveness; Funding; Grant; Institution; Lithium; Manic; Outcome; Phase; Protocols documentation; Psychopharmacology; Psychosocial Factor; Research; Research Personnel; Resources; Risperidone; Source; United States National Institutes of Health; design; valproate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall aim of this study is to perform a collaborative, multisite psychopharmacology effectiveness study of 6.0-15 years old (N=540) who have DSM-IV (mania or mixed phase) or mania. The specific aims of this protocol are: (1) To investigate the effectivness of lithium, valproate and resperidone as monotherapy and as add-on agents for childhood BP-1 (manic or mixed phase) disorder (2) To pilot a complex, multistrata, adaptive strategy design (3) to explore the effects of psychosocial factors on discontinuation, compliance and outcome.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究的总体目标是对患有 DSM-IV（躁狂或混合相）或躁狂的 6.0-15 岁 (N=540) 患者进行协作、多中心精神药理学有效性研究。 该方案的具体目标是： (1) 研究锂、丙戊酸盐和利培酮作为单一疗法和附加药物治疗儿童 BP-1（躁狂期或混合期）障碍的有效性 (2) 试点复杂的多层次治疗、适应性策略设计（3）探讨心理社会因素对停药、依从性和结果的影响。