TAAR1 POLYMORPHISMS IN RHESUS MONKEYS

恒河猴中的 TAAR1 多态性

• 批准号: 8357967
• 负责人: GREGORY MICHAEL MILLER
• 金额: $ 1.38万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357967
• 关键词: Amines; Behavior; Brain; Disease; Drug Addiction; Funding; Gene Family; Genes; Genetic Polymorphism; Grant; Human; Laboratories; Macaca mulatta; Mammals; National Center for Research Resources; New England; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Rodent; Source; System; United States National Institutes of Health; Variant; base; cost; genetic variant; monoamine; nervous system disorder; neuropsychiatry; novel; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The emerging importance of the TAAR1 receptor in modulating brain monoamine systems provides a strong rationale for determining whether polymorphic variation at the locus is functional and examining the significant similarities between human and rhesus monkeys, as well as other species. We have applied our laboratory's significant expertise in assessing TAAR1 function, polymorphism discovery in rhesus monkey genes associated with drug addiction and neuropsychiatric disorders, and genetic variant functional assessments to investigate of the TAAR1 locus. We identified novel genetic polymorphisms in both the rhesus monkey and human TAAR1, and have found that across species, only the caniform carnivores have a deleted gene. The gene family has seen expansions among certain mammals, notably rodents, and reductions in others, including primates. By placing the trace amine associated receptors in an evolutionary context we can better understand their function and their potential associations with behavior and neurological disease.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 TAAR1受体在调节脑单胺系统中的新出现的重要性为确定基因座的多态性变化是否功能性，并检查人类和恒河猴以及其他物种之间的显着相似性。我们已经应用了实验室在评估TAAR1功能，与药物成瘾和神经精神疾病相关的恒河猴基因的多态性发现以及遗传变异功能评估中的多态性专业知识，以研究TAAR1基因座。我们确定了恒河猴和人类TAAR1中的新型遗传多态性，并发现在整个物种中，只有罐装食肉动物具有缺失的基因。该基因家族已经看到了某些哺乳动物的扩张，尤其是啮齿动物，以及包括灵长类动物在内的其他哺乳动物的膨胀。通过将痕量胺相关受体放置在进化环境中，我们可以更好地了解其功能以及它们与行为和神经疾病的潜在关联。