GENE EXPRESSION DURING H PYLORI-HOST INTERACTION

幽门螺杆菌-宿主相互作用期间的基因表达

• 批准号: 8357261
• 负责人: JAY V. SOLNICK
• 金额: $ 5.04万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357261
• 关键词: California; Disease; Funding; Gastric mucosa; Gastritis; Gene Expression; Genes; Grant; Helicobacter pylori; Human; Immune response; Infection; Inflammatory Infiltrate; Macaca mulatta; Modeling; National Center for Research Resources; Pathogenesis; Peptic Ulcer; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; Virulence; cost; malignant stomach neoplasm

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Helicobacter pylori causes an inflammatory infiltrate in gastric mucosa that in about 10% of cases progresses to peptic ulcer disease or gastric cancer. Disease results from an interaction between strain-specific bacterial virulence genes and the particular host response, neither of which is well understood. Since experimental inoculation of rhesus macaques with H. pylori causes gastritis that closely mimics human infection, this model provides a unique opportunity to further our understanding of H. pylori pathogenesis.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 幽门螺杆菌在胃粘膜中引起炎症性浸润，在大约10％的病例中发展为消化性溃疡疾病或胃癌。疾病是由于菌株特异性细菌毒力基因与特定宿主反应之间的相互作用而产生的，疾病均未得到充分理解。由于用幽门螺杆菌对恒河猕猴进行实验接种会导致胃炎密切模仿人类感染，因此该模型为我们提供了一个独特的机会，可以进一步了解我们对幽门螺杆菌发病机理的理解。