EARLY DIAGNOSIS OF NOSOCOMIAL CANDIDIASIS

院内念珠菌病的早期诊断

• 批准号: 7952056
• 负责人: KRISTI L. WATTERBERG
• 金额: $ 0.21万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7952056
• 关键词: Blood; Candida; Candidiasis; Clinical; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Diagnostic tests; Early Diagnosis; Enrollment; Funding; Gene Expression; Grant; Incidence; Institution; Judgment; Modeling; Neonatal; New Mexico; Organ; Patients; Pattern; Research; Research Personnel; Resistance; Resources; Risk; Source; Stratification; Testing; United States National Institutes of Health; Universities; clinical practice; neonate; novel diagnostics

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Primary Aims of this study are: 1) Prospectively evaluate three new diagnostic tests for invasive neonatal candidiasis. 2) Develop a risk-stratification model on clinical presentation. 3) Test the peformance of the clinical model against the judgment of bedside clinicians. Secondary Aims: 1) Determine cumulative incidence for end-organ damage in those neonates who are evaluated for end-organ damage in accordance with Good Clinical Practice (GCP). 2) Determine resistance patterns and gene expression by Candida isolated from the blood of enrolled patients.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究的主要目的是： 1) 前瞻性评估三种新的侵袭性新生儿念珠菌病诊断测试。 2) 开发临床表现的风险分层模型。 3) 根据床边临床医生的判断测试临床模型的性能。 次要目标： 1) 确定根据良好临床实践 (GCP) 评估终末器官损伤的新生儿的终末器官损伤累积发生率。 2) 确定从入组患者血液中分离的念珠菌的耐药模式和基因表达。