Mentoring of Clinical Investigators in Patient Oriented Research

指导临床研究人员进行以患者为导向的研究

• 批准号: 8300484
• 负责人: Eric C. Strain
• 金额: $ 18.57万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8300484
• 关键词: Absence of pain sensation; Acute; Acute Pain; Address; Adverse effects; Analgesics; Area; Back; Behavior Therapy; Buprenorphine; CYP2D6 gene; Chronic; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Clonidine; Cocaine Dependence; Commit; Comorbidity; Data; Development; Doctor of Medicine; Dose; Double-Blind Method; Drug Metabolic Detoxication; Drug abuse; Enrollment; Environment; Faculty; Funding; Generations; Genotype; Goals; Grant; Growth; Human; Hydromorphone; Institution; Institutional National Research Service Award; Intervention; Journals; Leadership; Measures; Mentors; Metabolism; Methadone; Methods; Midcareer Investigator Award in Patient-Oriented Research; Morphine; Naltrexone; Opiate Addiction; Opioid; Opioid Analgesics; Oral; Outcome Measure; Pain; Pain Threshold; Pain management; Paper; Participant; Patients; Peer Review; Perception; Persons; Pharmaceutical Preparations; Pharmacological Treatment; Phase; Physicians; Placebos; Population; Postdoctoral Fellow; Procedures; Process; Productivity; Psychiatry; Psychologist; Public Health; Randomized; Recommendation; Recruitment Activity; Reporting; Request for Applications; Research; Research Personnel; Research Project Grants; Role; Safety; Science; Scientist; Sensory; Stimulus; Stratification; Study Section; Subgroup; Substance Use Disorder; Substance abuse problem; Symptoms; Testing; Time; Training; Training Programs; Tramadol; Treatment outcome; United States National Institutes of Health; Universities; Withdrawal; Withdrawal Symptom; Woman; Work; addiction; behavioral pharmacology; career; comparative efficacy; drug metabolism; evidence base; experience; innovation; interest; medical schools; member; men; next generation; novel; opioid withdrawal; patient oriented; patient oriented research; primary outcome; programs; psychologic; response; responsible research conduct; secondary outcome; substance abuse treatment; trial comparing

DESCRIPTION (provided by applicant): This is a competing renewal application for a K24 Midcareer Investigator Award in Patient-Oriented Research (POR). The applicant is Eric C. Strain, a physician-researcher in the Department of Psychiatry at Johns Hopkins University School of Medicine. Dr. Strain has devoted his career to POR, and specifically to issues related to research on drug abuse and to treatment of substance abusing patients. His areas of focus have included (among others) the development of medications for the treatment of opioid and cocaine dependence, the testing of medications combined with behavioral treatment interventions, the role of psychiatric symptoms and comorbidity in substance use disorders, the testing of abuse liability of medications, and the special treatment needs of women and men with substance abuse. Over the past five years of funding for this K24, he has also shifted time and effort to the recruitment and development of fellows and junior faculty members who are interested in POR related to substance use disorders. He is in an excellent environment for such work; he is at a major academic research institution (Johns Hopkins), he is a member of a productive research group (the Behavioral Pharmacology Research Unit [BPRU]), and the BPRU has a well-established T32 training program for post-doctoral fellows (directed by Dr. George Bigelow; the candidate is a faculty member of that program, and post-doctoral mentees for this K24 have been enrolled in and supported by the T32 program). The candidate's career goals and objectives are related to the development of a next generation of clinician investigators in addictions-related POR; in addition, the candidate's personal goals are related to his own continued research productivity (which will occur concurrent with his mentoring activities, and facilitate the mentoring process). His immediate goals and objectives relate to the recruitment and development of young clinical investigators who show potential to develop as independently funded investigators committed to POR in addictions. In addition, he has more immediate goals related to continued independent funding and productivity as measured by peer-reviewed papers and scientific presentations, and related to contributions to the broader field of addictions science (e.g., through editing of a journal, and through committee work such as chair of a study section). His longer-term goals relate to the establishment of the next generation of clinician scholars working in the area of addictions at Hopkins, which is expected to be ongoing and to extend beyond the five years of funding that would be provided by this K24. The candidate has the strong backing of his institution and departmental leadership, and is committed to all features of the mentoring process (including his own training as well as the training of mentees in the responsible conduct of research). He has a strong and sustained track record of NIH-funded research, and the past five years of K24 funding show that he has been able to successfully recruit graduating physician residents as well as psychologists and help them begin their clinical research careers. This application provides examples of two research projects; one related to the candidate's own funded work, and the second related to one of his mentee's interests. In summary, the K24 mechanism has been an ideal means for supporting this candidate's research and growth as a clinician investigator and mentor, and continued funding for Dr. Strain will provide continuity and continued growth in the development of a next generation of clinician investigators devoted to patient oriented research in addictions. PUBLIC HEALTH RELEVANCE: Mentoring of young clinical investigators interested in addictions is needed. This renewal application requests continued support for a clinician-scientist, Eric C. Strain, M.D., who has provided mentoring support to young investigators at Johns Hopkins University. These mentoring activities will continue to help develop a new generation of patient oriented researchers who are dedicated to the study and advancement of our understanding and treatment of substance use disorders.

描述（由申请人提供）：这是针对以患者为导向的研究（POR）的K24中级护理研究者奖的竞争续订申请。申请人是约翰·霍普金斯大学医学院精神病学系的医师研究员Eric C. Strain。克林博士将自己的职业生涯致力于POR，特别是针对与药物滥用研究和治疗虐待患者有关的问题。他的重点领域包括（除其他外）开发用于治疗阿片类药物和可卡因依赖性的药物，药物的测试与行为治疗干预措施相结合，精神症状和合并症在物质使用障碍中的作用，药物虐待责任的测试以及药物和男性的特殊治疗责任需求。在过去的五年中，他为这项K24提供了资金，他还将时间和精力转移到了对与药物使用障碍有关的POR感兴趣的研究员和初级教师的招聘和发展。他正处于这样的工作环境中。他是一家主要的学术研究机构（Johns Hopkins），是一名生产研究小组（行为药理学研究部门[BPRU]）的成员，而BPRU拥有一项良好的T32 T32培训计划，专门为乔治·比格洛（George Bigelow）指导的医生，由该计划的教师和后的培训者培养在该计划中； T32程序）。候选人的职业目标和目标与下一代与成瘾有关的临床研究者的发展有关；此外，候选人的个人目标与他自己的持续研究生产力有关（这将与他的指导活动同时发生，并促进指导过程）。他的直接目标和目标与 年轻的临床研究人员的招募和发展，他们表现出发展为独立资助的研究人员，他们致力于成瘾。此外，通过同行评审的论文和科学演示，他具有与持续的独立资金和生产力有关的更直接的目标，并且与对更广泛的成瘾科学领域的贡献有关（例如，通过杂志的编辑以及通过委员会的工作，例如研究部分的委员会工作）。他的长期目标涉及建立下一代在霍普金斯成瘾领域工作的临床学者，这预计将持续不断，并超越本K24提供的五年资金。候选人得到了他的机构和部门领导力的强烈支持，并致力于指导过程的所有特征（包括他自己的培训以及对负责任的研究的培训）。他在NIH资助的研究中拥有稳定而持续的记录，过去五年的K24资助表明，他已经能够成功招募毕业的医师居民以及心理学家，并帮助他们开始临床研究职业。该应用程序提供了两个研究项目的示例；一种与候选人自己的资助工作有关，第二个与他的受训者的利益有关。总而言之，K24机制是支持该候选人作为临床研究者和导师的研究和成长的理想手段，而Wearter博士继续提供资金，将为下一代临床研究人员提供连续性和持续增长，致力于成瘾中面向患者研究的临床研究者。 公共卫生相关性：需要对成瘾感兴趣的年轻临床研究人员进行指导。该更新申请要求继续支持临床医生科学家，M.D。Eric C. Strain，他为Johns Hopkins University的年轻调查员提供了指导的支持。这些指导活动将继续有助于发展新一代以患者为导向的研究人员，这些研究人员致力于研究和进步我们对药物使用障碍的理解和治疗。