Mentoring of Clinical Investigators in Patient Oriented Research

指导临床研究人员进行以患者为导向的研究

• 批准号: 8064793
• 负责人: Eric C. Strain
• 金额: $ 18.41万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8064793
• 关键词: Address; Agonist; Analgesics; Area; Award; Behavior Therapy; Biological Availability; Buprenorphine; Characteristics; Clinical; Clinical Investigator; Clinical Pharmacology; Clinical Research; Clinical Trials; Cocaine Abuse; Cocaine Dependence; Communities; Comorbidity; Development; Disease; Dose; Drug Addiction; Drug abuse; Environment; Faculty; Fellowship; Funding; Goals; Grant; Human; Intervention; Laboratory Study; Lead; Maintenance; Mentors; Mentorship; Mission; National Institute of Drug Abuse; New Agents; Opiate Addiction; Opioid; Oral; Patients; Persons; Pharmaceutical Preparations; Pharmacotherapy; Physical Dependence; Physicians; Pilot Projects; Positioning Attribute; Psychiatry; Recruitment Activity; Relative (related person); Reporting; Research; Research Personnel; Research Support; Resources; Role; Safety; Schedule; Scientific Advances and Accomplishments; Series; Substance Use Disorder; Substance abuse problem; Symptoms; Testing; Training; Tramadol; United States; United States Food and Drug Administration; United States National Institutes of Health; Universities; Woman; Work; addiction; base; career; cocaine use; efficacy testing; experience; medical schools; member; men; mu opioid receptors; next generation; opioid withdrawal; patient oriented research; prescription opioid; substance abuse treatment

DESCRIPTION (provided by applicant): This is an application for a K24 Mid-career Investigator Award in Patient Oriented Research (POR). The applicant is Eric Strain, a physician-researcher in the Department of Psychiatry at Johns Hopkins University School of Medicine. Dr. Strain has devoted his career to POR, and specifically to issues related to research on drug abuse and to treatment of substance abusing patients. His areas of focus have included the development of medications for the treatment of opioid and cocaine dependence, the testing of medications combined with behavioral treatment interventions, the role of psychiatric symptoms and comorbidity in substance use disorders, the testing of abuse liability of medications, and the special treatment needs of women and men with substance abuse. This application describes the candidate's three immediate career goals (to recruit young physicians/clinical investigators to conduct research fellowships in clinical addictions research, to integrate these clinical investigators into ongoing and new studies of POR conducted at the BPRU by providing direct experience in all aspects of clinical investigation, and to assist and mentor these clinical investigators in the transition from fellow to junior faculty member, encouraging each to continue in a career path of addictions-related research). In addition, three long-term career goals are also described (to develop a group of junior, mid-level, and senior clinician investigators with expertise in conducting addictions-related research to serve as a next generation of investigators in substance abuse research at Johns Hopkins, to maintain current investigative strengths of the BPRU while building new complementary areas of clinical research through collaborative efforts within the research community, and to utilize this investigative team in advancing scientific understanding of addictive disorders and their treatment through coordinated efforts). These goals will be accomplished through currently funded research efforts, and a clinical pharmacology study is succinctly presented to illustrate work currently funded by the candidate. In addition, funds from the present application will be used for pilot studies to be conducted with young clinicians, and the research plan for a study comparing tramadol to buprenorphine for the treatment of opioid withdrawal is presented. This work is highly relevant to the mission of NIH and NIDA. Recruiting and training young clinical investigators in the area of addictions are needed to advance understanding and treatment of these disorders. The applicant is well positioned to recruit young clinical investigators, has experience in successfully mentoring young researchers, and is in a strong research environment with excellent resources for mentoring and providing high quality clinical research experiences.

描述（由申请人提供）：这是针对患者研究（POR）的K24中级研究员奖的申请。申请人是约翰·霍普金斯大学医学院精神病学系的医师研究人员Eric Strain。克林博士将自己的职业生涯致力于POR，特别是针对与药物滥用研究和治疗虐待患者有关的问题。他的重点领域包括开发用于治疗阿片类药物和可卡因依赖性的药物，对药物的测试以及行为治疗干预措施的测试，精神症状的作用和合并症在药物使用障碍中的作用，药物滥用责任的测试以及药物滥用药物的特殊治疗方法。该申请描述了候选人的三个直接职业目标（招募年轻的医师/临床研究人员，以在临床成瘾研究中进行研究奖学金，以将这些临床研究人员整合到BPRU进行的POR的持续和新研究中，通过在临床研究的各个方面提供直接的经验，并在临床研究中提供这些临床研究的各个方面，以帮助和指导他们在临床研究中，从而使这些临床调查人员在过渡方面的发展，以使他们的临床调查人员在Jun的临床研究中，从而使Jun的成员在Jun的临床研究中提供进一步的发展。与成瘾有关的研究）。 In addition, three long-term career goals are also described (to develop a group of junior, mid-level, and senior clinician investigators with expertise in conducting addictions-related research to serve as a next generation of investigators in substance abuse research at Johns Hopkins, to maintain current investigative strengths of the BPRU while building new complementary areas of clinical research through collaborative efforts within the research community, and to utilize this investigative team in advancing scientific understanding of addictive通过协调的努力疾病及其治疗）。这些目标将通过当前资助的研究工作来实现，并简洁地提出了一项临床药理学研究，以说明当前由候选人资助的工作。此外，本申请的资金将用于与年轻临床医生一起进行的试点研究，并提出了将曲马多与丁丙诺啡进行比较的研究计划，以治疗阿片类药物的戒断。这项工作与NIH和NIDA的使命高度相关。需要招募和培训成瘾领域的年轻临床研究人员，以提高对这些疾病的理解和治疗。申请人在招募年轻的临床研究人员，拥有成功指导年轻研究人员方面的经验，并且在强大的研究环境中拥有良好的资源，可以指导和提供高质量的临床研究经验，并拥有良好的研究环境。