NEUROCOGNITIVE PROGNOSIS IN SURVIVORS OF BRAIN TUMORS

脑肿瘤幸存者的神经认知预后

• 批准号: 7951249
• 负责人: ELANA FARACE
• 金额: $ 0.28万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951249
• 关键词: Brain Neoplasms; Cancer Patient; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Equation; Funding; Goals; Grant; Impaired cognition; Institution; Length; Malignant neoplasm of brain; Modeling; Neurocognitive; Patients; Population; Quality of life; Research; Research Personnel; Resources; Source; Survivors; Testing; Time; United States National Institutes of Health; end of life; improved; neuro-oncology; neuropsychological; outcome forecast; patient population; survivorship

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The central tenet of the proposed research is that including neuropsychological variables can improve understanding of patients' QOL, elucidate QOL trajectory to end-of-life, and help predict length of survival in malignant brain tumor patient populations. In order to test this proposal, structural equation modeling will be performed to determine inter-relationships of components of QOL, their trajectory over time, and the extent to which QOL predicts patient survival. Results will have implications not only for neuro-oncology, but also for all cancer patients with cognitive impairment, contributing to improved QOL and survivorship for these populations. The ultimate goal is to maximize both survival and QOL.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 拟议研究的中心宗旨是，纳入神经心理学变量可以提高对患者生活质量的理解，阐明到生命终结的生活质量轨迹，并帮助预测恶性脑肿瘤患者群体的生存长度。为了测试这一提议，将进行结构方程建模，以确定 QOL 各组成部分的相互关系、它们随时间的轨迹以及 QOL 预测患者生存的程度。结果不仅对神经肿瘤学产生影响，而且对所有患有认知障碍的癌症患者产生影响，有助于改善这些人群的生活质量和生存率。最终目标是最大限度地提高生存率和生活质量。