CLINICAL TRIAL: BETA-AMYLOID PROBES OF ALZHEIMER'S DISEASE

临床试验：阿尔茨海默病的 β-淀粉样蛋白探针

• 批准号: 7951523
• 负责人: GARY William SMALL
• 金额: $ 1.81万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951523
• 关键词: Affect; Age; Amyloid beta-Protein; Brain; Brain region; Clinical Research; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Disease; Disease Progression; Funding; Genetic Risk; Grant; Institution; Intervention; Monitor; Patients; Pattern; Positron-Emission Tomography; Research; Research Personnel; Resources; Source; Testing; United States National Institutes of Health; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our aim is to test 3 hypotheses: 1)PET imaging shows highest FDDNP concentrations in AD-affected brain regions in AD patients, intermediate concentrations in MCI, and lowest in age-matched controls. 2)FDDNP-PET and FDG-PET imaging patterns are inversely correlated. 3)Subjects with APOE-4 have greater FDDNP brain concentrations than those without this genetic risk for AD. These studies may eventually provide a safe, effective, and practical means for 1) early presymtomatic diagnosis, and 2) monitoring disease progression and efficacy of novel pharmacologic interventions.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们的目的是检验 3 个假设：1)PET 成像显示 AD 患者受 AD 影响的大脑区域 FDDNP 浓度最高，MCI 中浓度中等，年龄匹配对照中 FDDNP 浓度最低。 2)FDDNP-PET和FDG-PET成像模式呈负相关。 3) 患有 APOE-4 的受试者比没有这种 AD 遗传风险的受试者脑中 FDDNP 浓度更高。 这些研究最终可能为 1) 早期症状前诊断和 2) 监测疾病进展和新型药物干预措施的疗效提供安全、有效和实用的方法。