Affective Instability and Features of Borderline Personality in Adolescent Girls

青春期女孩情感不稳定与边缘人格特征

基本信息

批准号：
8212481
负责人：
STEPHANIE D STEPP
金额：
$ 14.29万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-03-29 至 2015-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8212481
关键词：
16 year old Acute Address Adolescence Adolescent Affect Affective Anger Anxiety Appointment Behavioral Biological Factors Borderline Personality Disorder Buffers Cereals Childhood Chronic Clinical Complement Complex Data Depressed mood Development Diagnosis Disease Educational process of instructing Emotional Emotions Environment Etiology Event Female Adolescents Functional disorder Goals Home environment Hour Impairment Individual Intervention Interview Interviewer Investigation K-Series Research Career Programs Laboratories Measures Memory Mentors Mentorship Methods Modeling Moods Mydriasis Parents Patient Self-Report Personality Physiological Play Population Positioning Attribute Prevention program Prevention strategy Procedures Psychophysiology Pupil Questionnaires Recruitment Activity Regulation Reporting Research Research Activity Research Methodology Research Training Risk Role Sampling Severities Silk Social Environment Specificity Stimulus Sum Testing Time Training Training Activity Training Programs Translational Research Validation Woman base behavioral health career development evidence base experience follow-up girls indexing interest intervention program parental influence parental role peer programs prospective research and development response skills social suicidal behavior theories tool translational approach young adult

项目摘要

DESCRIPTION (provided by applicant): The goal of this Research Career Development Award (K01) is to provide a five-year career development and research training program that will enable the candidate to conduct research on the role of affective instability (AI) in the development of Borderline Personality Disorder (BPD) during childhood and adolescence in girls. BPD is a complex and debilitating disorder associated with frequent suicidal behavior, intense and chronic misery, and high rates of treatment utilization. BPD is usually first diagnosed in young adulthood and is disproportionately diagnosed in women. There are four key features of BPD: AI, interpersonal dysfunction, behavioral undercontrol, and identity disturbance. Major theories suggest that AI plays a primary role in the development of BPD and that parental response to affect is especially important in buffering or conferring risk for those girls with high levels of AI. However, little longitudinal research has been conducted on etiological mechanisms underlying the developmental course of BPD. To address this need, the training and research plan incorporates both behavioral and psychophysiological approaches in a longitudinal framework to investigate the role of AI in the development of other features of BPD in adolescent girls. The candidate will pursue training in developmental research methodology pertinent to adolescent girls, assessment of affect in the natural environment using ecological momentary assessment (EMA), and the psychophysiology of emotion under the mentorship of Dr. Paul Pilkonis, co-mentor Greg Siegle, and an expert team of consultants, including Drs. Rolf Loeber and Ronald Dahl. The proposed research will utilize EMA, psychophysiological (pupillometry), and questionnaire measures to examine associations between AI and other features of BPD in adolescent girls over time. Additionally, the impact of parental response to affect on features of BPD will be examined. The proposed research goals will be achieved in a prospective substudy of a longitudinal investigation of girls' emotional and behavioral health (Pittsburgh Girls Study: PGS). This project will recruit 110 16 year-old girls from the PGS, sampling the full range of AI severity. These training and research activities will place the candidate in a position to conduct translational research on social and biological factors in the etiology of BPD.

描述（由申请人提供）：该研究职业发展奖（K01）的目标是提供为期五年的职业发展和研究培训计划，使候选人能够对情感不稳定（AI）在社会中的作用进行研究。女孩在童年和青春期出现边缘性人格障碍（BPD）。 BPD 是一种复杂且令人衰弱的疾病，与频繁的自杀行为、强烈和慢性的痛苦以及高治疗利用率相关。 BPD 通常在青年时期首次被诊断出来，并且在女性中被诊断出来的比例不成比例。 BPD 有四个主要特征：AI、人际功能障碍、行为失控和身份障碍。主要理论表明，人工智能在边缘性人格障碍的发展中起着主要作用，而父母对情感的反应对于缓冲或赋予人工智能水平高的女孩风险尤其重要。然而，对于BPD发展过程背后的病因机制却很少进行纵向研究。为了满足这一需求，培训和研究计划将行为和心理生理学方法纳入纵向框架中，以研究人工智能在青春期女孩 BPD 其他特征发展中的作用。候选人将在 Paul Pilkonis 博士、联合导师 Greg Siegle 和专家顾问团队，包括博士。罗尔夫·勒伯和罗纳德·达尔。拟议的研究将利用 EMA、心理生理学（瞳孔测量）和问卷调查措施来检查 AI 与青春期女孩 BPD 其他特征之间的关联。此外，还将检查父母对边缘性人格障碍特征的反应的影响。拟议的研究目标将通过对女孩情绪和行为健康的纵向调查的前瞻性子研究（匹兹堡女孩研究：PGS）来实现。该项目将从 PGS 招募 110 名 16 岁女孩，对人工智能严重程度的全方位进行采样。这些培训和研究活动将使候选人能够对 BPD 病因学中的社会和生物因素进行转化研究。