NEUROSCIENCE CORE CENTER

神经科学核心中心

• 批准号: 8235769
• 负责人: FRANCIS W FLYNN
• 金额: $ 98.84万
• 依托单位: UNIVERSITY OF WYOMING
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8235769
• 关键词: Address; Alzheimer' s Disease; Biological Models; Biomedical Research; Brain; Centers of Research Excellence; Collaborations; Data; Development; Disease; Electron Microscope; Faculty; Fostering; Funding; Goals; Grant; Health; Human; Huntington Disease; Life; Mentors; Microscopy; Molecular; Morphology; National Center for Research Resources; Nerve Degeneration; Nervous system structure; Neurodegenerative Disorders; Neurons; Neurosciences; Optics; Parkinson Disease; Pathway interactions; Phase; Positioning Attribute; Prion Diseases; Research; Research Infrastructure; Research Personnel; Research Project Grants; Staging; Structure; Synapses; Synaptic plasticity; Therapeutic Intervention; United States National Institutes of Health; Universities; Wyoming; career; career development; chronic pain; experience; innovation; meetings; nervous system disorder; programs; protein misfolding; relating to nervous system; success

DESCRIPTION (provided by applicant): This Transition Center PSO application is a continuation of the Neuroscience COBRE at the University of Wyoming (UW). The Center goals were to develop a critical mass of neuroscience faculty, foster biomedical research in neurological disorders, increase NIH funding at UW, establish a Career Mentoring program, and develop the required research infrastructure, specifically the Microscopy Core. These goals have been met and the success of the Neuroscience Center and the development of the Microscopy Core is directly attributable to the NCRR COBRE grant, and secondly to the significant institutional commitment. UW provided 7 state-funded, tenure track neuroscience positions to the Center and state funding for the Microscopy Core Director. The Microscopy Core is essential to the success of the Neuroscience Center investigators and additional biomedical researchers on campus. The Core Director provides technical guidance in the use of the optical and electron microscopes in the facility. The Microscopy Core has enabled investigators to identify how normal synaptic connections are formed and the effects of protein misfolding on neuronal morphology in neurodegeneration. The Phase III grant will support Career Development, Pilot Research Projects (for assembling preliminary data for grants), and the Microscopy Core. Plans to sustain the Core following the completion of the Phase III transition grant are identified. Research progress of Center investigators has led to new hypotheses and experimental questions pertaining to how nervous system morphology and function changes with the life-stage, disease, experience, and experimental manipulation. The Neuroscience Center will provide the structure for building innovative and productive collaborations that address major biomedical issues related to mechanisms of synaptic plasticity, neurodegeneration, and chronic pain. Prion diseases are a prototypic protein misfolding disease and they share many molecular and pathological features with the more frequent human neurodegenerative disorders, e.g. Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD). New collaborative projects are identified that will utilize model systems that enable us to bridge between protein misfolding pathways and the downstream functional effects on neuronal activity and brain circuits, and common ways for therapeutic intervention.

描述（由申请人提供）：此过渡中心PSO申请是怀俄明大学（UW）的神经科学柯布雷的延续。中心目标是开发大量的神经科学教师，促进神经系统疾病的生物医学研究，增加UW的NIH资金，建立职业指导计划，并开发所需的研究基础设施，特别是显微镜核心。这些目标已经实现，神经科学中心的成功，显微镜核心的发展直接归因于NCRR毛绒赠款，其次是重大的机构承诺。 UW为Microscopy Core主管提供了7个国家资助的终身轨道神经科学职位和国家资助。显微镜核心对于神经科学中心研究人员和校园中其他生物医学研究人员的成功至关重要。核心主管提供了在设施中使用光学显微镜和电子显微镜的技术指导。显微镜核心使研究人员能够确定如何形成正常的突触连接以及蛋白质错误折叠对神经变性中神经元形态的影响。第三阶段赠款将支持职业发展，试点研究项目（用于组装赠款的初步数据）和显微镜核心。确定了第三阶段过渡赠款后维持核心的计划。中心研究人员的研究进度导致了与神经系统形态和功能如何随着生命阶段，疾病，经验和实验性操纵的变化有关的新假设和实验问题。神经科学中心将为建立创新和生产性合作提供结构，以解决与突触可塑性，神经变性和慢性疼痛机制相关的主要生物医学问题。病毒疾病是一种原型蛋白质错误折叠疾病，它们具有许多分子和病理特征，具有更频繁的人类神经退行性疾病，例如阿尔茨海默氏病（AD），帕金森氏病（PD）和亨廷顿氏病（HD）。确定了新的协作项目，该项目将利用模型系统，使我们能够在蛋白质错误折叠途径和下游功能对神经元活动和脑电路的功能以及治疗干预的常见方法之间桥接。