Repository for the Family Investigation of Nephropathy & Diabetes (FIND)

肾病家庭调查资料库

• 批准号: 8350796
• 负责人: DAVID HEIMBROOK
• 金额: $ 4.51万
• 依托单位: LEIDOS BIOMEDICAL RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2018-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8350796
• 关键词: Affect; Cell Line; Charge; Chronic; Cryopreserved Cell; Databases; Diabetes Mellitus; Diabetic Nephropathy; Disease; End stage renal failure; Family; Genes; Genetic Predisposition to Disease; Goals; Hyperglycemia; Hypertension; Individual; Institution; Intervention; Investigation; Kidney Diseases; Link; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Insulin-Dependent Diabetes Mellitus; Patients; Phenotype; Plasma; Predisposition; Prognostic Factor; Research Personnel; Sampling; Secure; Urine; genetic technology; repository; sample collection

Diabetic nephropathy (DN) is a multifactoral disease, and a large proportion of patients affected with either type 1 or type 2 diabetes develop diabetic nephropathy and progress to end stage renal disease (ESRD). When poor prognostic factors such as hypertension and chronic hyperglycemia are aggressively treated, the rate of progression of diabetic nephropathy can be slowed. However, no interventions have been shown to reliably halt the progression of diabetic nephropathy. Numerous studies have suggested that genetic predisposition to diabetic nephropathy exists, but genes for nephropathy have not yet been isolated. It is anticipated that a comprehensive analysis of a large number of uniformly phenotyped ESRD families will be necessary to isolated genes for ESRD. Such a database of families may not be available at any single institution. The charge of the FIND consortium was to acquire sets of families and individuals with well-characterized diabetic nephropathy, establish a secure master FIND database, and use genetic technologies to identify chromosomal regions linked with diabetic nephropathy in order to identify diabetic nephropathy susceptibility or protection genes. A Repository of samples collected during the FIND is essential for the FIND study to achieve its goals and for subsequent studies of this valuable sample collection.

糖尿病肾病 (DN) 是一种多因素疾病，大部分 1 型或 2 型糖尿病患者会发展为糖尿病肾病并进展为终末期肾病 (ESRD)。当高血压和慢性高血糖等不良预后因素得到积极治疗时，糖尿病肾病的进展速度可以减慢。然而，尚无干预措施能够可靠地阻止糖尿病肾病的进展。大量研究表明糖尿病肾病存在遗传倾向，但尚未分离出肾病基因。预计需要对大量表型一致的 ESRD 家族进行全面分析，以分离 ESRD 基因。任何一个机构都可能无法提供这样的家庭数据库。 FIND联盟的职责是获取具有明确特征的糖尿病肾病的家庭和个人，建立安全的FIND主数据库，并利用遗传技术识别与糖尿病肾病相关的染色体区域，从而识别糖尿病肾病的易感基因或保护基因。 FIND 期间收集的样本存储库对于 FIND 研究实现其目标以及对这一宝贵样本收集的后续研究至关重要。