Repository for the Family Investigation of Nephropathy & Diabetes (FIND)

肾病家庭调查资料库

• 批准号: 8350796
• 负责人: DAVID HEIMBROOK
• 金额: $ 4.51万
• 依托单位: LEIDOS BIOMEDICAL RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2018-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8350796
• 关键词: Affect; Cell Line; Charge; Chronic; Cryopreserved Cell; Databases; Diabetes Mellitus; Diabetic Nephropathy; Disease; End stage renal failure; Family; Genes; Genetic Predisposition to Disease; Goals; Hyperglycemia; Hypertension; Individual; Institution; Intervention; Investigation; Kidney Diseases; Link; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Insulin-Dependent Diabetes Mellitus; Patients; Phenotype; Plasma; Predisposition; Prognostic Factor; Research Personnel; Sampling; Secure; Urine; genetic technology; repository; sample collection

Diabetic nephropathy (DN) is a multifactoral disease, and a large proportion of patients affected with either type 1 or type 2 diabetes develop diabetic nephropathy and progress to end stage renal disease (ESRD). When poor prognostic factors such as hypertension and chronic hyperglycemia are aggressively treated, the rate of progression of diabetic nephropathy can be slowed. However, no interventions have been shown to reliably halt the progression of diabetic nephropathy. Numerous studies have suggested that genetic predisposition to diabetic nephropathy exists, but genes for nephropathy have not yet been isolated. It is anticipated that a comprehensive analysis of a large number of uniformly phenotyped ESRD families will be necessary to isolated genes for ESRD. Such a database of families may not be available at any single institution. The charge of the FIND consortium was to acquire sets of families and individuals with well-characterized diabetic nephropathy, establish a secure master FIND database, and use genetic technologies to identify chromosomal regions linked with diabetic nephropathy in order to identify diabetic nephropathy susceptibility or protection genes. A Repository of samples collected during the FIND is essential for the FIND study to achieve its goals and for subsequent studies of this valuable sample collection.

糖尿病性肾病（DN）是一种多因素疾病，很大一部分患有1型或2型糖尿病的患者会出现糖尿病性肾病，并进展到终结阶段肾病（ESRD）。当对高血压和慢性高血糖等较差的预后因素受到积极治疗时，糖尿病性肾病的进展率可以减慢。但是，尚未证明干预措施可靠地停止糖尿病性肾病的进展。大量研究表明，存在遗传性糖尿病性肾病的易感性，但尚未分离出肾病的基因。可以预料，对于ESRD的孤立基因，必须对大量统一表型ESRD家族进行全面分析。任何单个机构都可能无法获得这样的家庭数据库。查找财团的指控是获取具有良好特征糖尿病性肾病的家庭和个体的集合，建立一个安全的大师查找数据库，并使用遗传技术来识别与糖尿病性肾病相关的染色体区域，以识别糖尿病性肾病性肾病易感性或保护基因。在发现过程中收集的样本的存储库对于发现研究的目标是至关重要的，以实现其目标以及对这一有价值的样本收集的随后研究。