Lung Health Study in the Agricultural Health Study

农业健康研究中的肺部健康研究

• 批准号: 8336646
• 负责人: Stephanie London
• 金额: $ 20.41万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8336646
• 关键词: Agriculture; Allergens; Allergic; Allergic Disease; Animals; Asthma; Attention; Cereals; Cohort Studies; Cross-Sectional Studies; Data; Data Collection; Development; Diesel Exhaust; Disease; Dust; Elderly; Endotoxins; Environmental Exposure; Exposure to; Farming environment; Follow-Up Studies; Genes; Genetic Variation; Health; Home visitation; House Call; Hypersensitivity; Immune response; Inflammatory; Inflammatory Response; Inflammatory Response Pathway; Insecticides; Iowa; Life; Lipopolysaccharides; Lung; Manure; Measures; Metabolism; Molecular; Morbidity - disease rate; North Carolina; Organophosphates; Outcome; Pathway interactions; Patient Self-Report; Pattern; Peptidoglycan; Pesticides; Phenotype; Questionnaires; Risk; Role; Sampling; Spouses; System; Testing; Time; Variant; Wheezing; Work; airway inflammation; atopy; base; beta-Glucans; cohort; comparison group; design; early life exposure; farmer; follow-up; gene environment interaction; interest; mortality; pathogen; pesticide exposure; respiratory; response; toxicant

To investigate the relationship between farming exposures and asthma, we have developed a case-cohort study within a large cohort of farmers -- the Agricultural Health Study. This study follows up findings regarding the association between correlates of exposure to pathogen associated molecular patterns (such as endotoxin) and various questionnaire-based asthma and atopy phenotypes. It is also designed to follow-up findings based on questionnaire data of positive associations between pesticide exposures, especially organophospates, and questionnaire-based asthma phenotypes. To confirm and better understand these associations, objective measures of asthma and atopy phenotype are needed along with more detailed and objective exposure assessment. Field work began in February 2009 and continues to date. This study builds upon the Agricultural Health Study, a large cohort of farmers and their spouses in Iowa and North Carolina. For case and noncase identification, we are using the third wave of questionnaire follow-up ongoing in the larger study. Our asthma add-on study involves making home visits with objective measures of exposure and asthma and allergy phenotypes on approximately 1,700 asthma cases and a random sample of the cohort as a comparison group (case-cohort design).

为了调查农业暴露与哮喘之间的关系，我们在一大群农民中开展了一项病例队列研究——农业健康研究。这项研究跟踪了有关暴露于病原体相关分子模式（例如内毒素）的相关性与各种基于问卷的哮喘和特应性表型之间的关联的发现。它还旨在根据农药暴露（尤其是有机磷酸酯）与基于问卷的哮喘表型之间正相关的问卷数据来跟踪调查结果。为了确认和更好地理解这些关联，需要对哮喘和特应性表型进行客观测量，并进行更详细和客观的暴露评估。实地工作于 2009 年 2 月开始并持续至今。 这项研究以农业健康研究为基础，该研究由爱荷华州和北卡罗来纳州的大量农民及其配偶组成。对于病例和非病例识别，我们正在使用大型研究中正在进行的第三波问卷调查。我们的哮喘附加研究包括对大约 1,700 例哮喘病例进行家访，客观测量暴露情况、哮喘和过敏表型，并随机抽取队列样本作为对照组（病例队列设计）。