Characterization of fungal exposures

真菌暴露的表征

基本信息

批准号：
8654909
负责人：
金额：
$ 13.37万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8654909
关键词：
Acute Address Adverse effects Aerosols Agreement Agriculture Air Allergens Allergic Allergic rhinitis Animal Model Antigens Aspergillus Asthma Biological Assay Biological Markers Breathing Caliber Chaetomium Child Childhood Chronic Disease Cities Collaborations Commercial Sectors DNA Data Data Set Development Diagnostic Disease Dust Environment Environmental Monitoring Epidemiologic Studies Evaluation Exposure to Extrinsic allergic alveolitis Farming environment Fungal Antigens Fungal Genes Fungal Spores General Population Genes Genome Genomics Goals Health Home environment Hospitals Human Hypersensitivity Hyphae IgE Infiltration Institutes Kansas Knowledge Libraries Lung Methodology Methods Minor Mission Modeling Molds Monoclonal Antibodies Morbidity - disease rate Mus Mycotoxins National Institute of Environmental Health Sciences Nose Occupational Occupational Health Opportunistic Infections Organism Paecilomyces Penetration Population Process Proteins Protocols documentation Publications RNA Sequences Reaction Reagent Recombinants Relative (related person)Reproduction spores Research Research Personnel Research Priority Ribosomal RNA Risk Risk Assessment Sampling Schools Serum Systemic infection Techniques Technology Testing United States United States National Academy of Sciences Waste Products Water Wood material Work Workplace Xenobiotics aerosolized air sampling base cohort design exposed human population farmer fungus immunotoxicity improved indexing particle pesticide exposure remediation research study respiratory

项目摘要

The Immunotoxicity of Workplace Xenobiotics interagency agreement functions to enhance the immunotoxicological evaluations of humans exposed to quantifiable levels of xenobiotics in the environment and workplace. Personal exposure to fungal bioaerosols and other mold related xenobiotics from contaminated building materials in the home or school environment is of growing concern in the general population, particularly in pediatric populations. In epidemiological studies, the inhalation of fungal spores, hyphae, and fragments has been associated with exacerbations of respiratory morbidity such as asthma, allergic rhinitis, and hypersensitivity pneumonitis. Certain occupational populations are also at elevated risk for fungal exposures including agriculture and horticultural workers that handle contaminated farm and bio-waste products in agricultural facilities, wood processing workers, as well as construction and remediation workers that handle contaminated building materials. Although fungal exposure has often been associated with allergic, toxic and/or infectious health effects, the actual potential of different fungi to exacerbate these adverse effects remains unclear. The National Academy of Sciences has recognized the need to develop better fungal exposure assessment methods as a high research priority. The NTP also has a major initiative for studying the health effects of fungal exposure. Personal exposure to airborne fungi and other fungal related xenobiotics has been associated with a variety of adverse health effects ranging from systemic and opportunistic infections, allergies, asthma, to toxic reactions. However, not all fungi are equally important and improved diagnostics are essential to develop informative exposure and surveillance techniques. The projects conducted as part of this interagency agreement support the NTP mission through the development of analytical reagents for improved species-specific identification of fungi and to better evaluate the health effects associated with fungal exposures. The knowledge gained from these projects will assist in the development of improved testing methods for the quantification of environmental fungi, as well as generate data that will strengthen the scientific base for fungal exposure risk assessment. These projects will additionally address specific NIOSH and NIEHS research goals for reducing environmental and occupational causes or contributing factors to acute and chronic illness and disease in worker populations as well as children.

工作场所异生物质的免疫毒性机构间协议旨在加强对环境和工作场所中暴露于可量化水平的异生物质的人类的免疫毒理学评估。在家庭或学校环境中，个人接触来自受污染建筑材料的真菌生物气溶胶和其他与霉菌相关的异生物质，引起了普通人群，特别是儿科人群越来越多的关注。在流行病学研究中，吸入真菌孢子、菌丝和碎片与哮喘、过敏性鼻炎和过敏性肺炎等呼吸道疾病的恶化有关。某些职业人群接触真菌的风险也较高，包括处理受污染农场和农业设施中生物废物的农业和园艺工人、木材加工工人以及处理受污染建筑材料的建筑和修复工人。尽管真菌暴露通常与过敏、毒性和/或传染性健康影响有关，但不同真菌加剧这些不利影响的实际潜力仍不清楚。美国国家科学院已认识到需要将开发更好的真菌暴露评估方法作为一项高度研究优先事项。 NTP 还开展了一项研究真菌暴露对健康影响的重大举措。个人接触空气中的真菌和其他真菌相关的外源物质与多种不良健康影响有关，包括全身性和机会性感染、过敏、哮喘和毒性反应。然而，并非所有真菌都同样重要，改进的诊断对于开发信息丰富的暴露和监测技术至关重要。作为该机构间协议的一部分进行的项目通过开发分析试剂来支持 NTP 使命，以改进真菌的物种特异性鉴定，并更好地评估与真菌暴露相关的健康影响。从这些项目中获得的知识将有助于开发改进的环境真菌定量测试方法，并生成数据以加强真菌暴露风险评估的科学基础。这些项目还将解决 NIOSH 和 NIEHS 的具体研究目标，以减少环境和职业原因或导致工人和儿童急性和慢性疾病的因素。